石棉相关的肺肿瘤发病机制研究进展  

Advance research of Asbestos-induced pulmonary tumor

作　　者：宾流 林子英[1] 刘刚[1] 

机构地区：[1]广东医学院附属医院呼吸内科,广东湛江524001

出　　处：《现代肿瘤医学》2014年第7期1694-1697,共4页Journal of Modern Oncology

基　　金：国家自然科学基金项目(编号:81172615)

摘　　要：石棉粉尘对人体危害很大,长期吸入能引起石棉肺、肺癌、胸膜间皮瘤等疾病。但是,目前石棉导致肺肿瘤相关的机制仍未阐明。石棉介导的氧化应激、慢性炎症、肿瘤相关信号通路的激活及细胞凋亡异常都可促使肿瘤形成,这些机制相互关联,形成复杂的关系网络,共同参与调节石棉诱导的肺肿瘤。本文就石棉导致肺肿瘤发病机制的最新进展进行综述。Multiple epidemiological studies of population with occupational and environmental exposures to respirable asbestos fibers have assessed risk for both pulmonary parenchymal fibrosis（asbestosis） and malignancies（ bronchogen- ic carcinoma and mesothelioma）, but the molecular mechanisms are not fully understood. Here, the current knowledge of the important pathogenic pathways involving oxidative stress, inflammation, apoptosis, and modulation of gene ex- pression and activation of transcription factors with important role in carcinogenesis were summarized.

关 键 词：石棉 肺肿瘤 氧化应激 慢性炎症 凋亡 

分 类 号：R734.2[医药卫生—肿瘤]