Current advances in neurotrauma research:diagnosis, neuroprotection,and neurorepair  

作　　者：Jinhui Chen Riyi Shi 

机构地区：[1]Department of Neurological Surgery, Stark Neuroscience Research Institute, Department of Anatomy, Indiana University School of Medicine,Indianapolis, IN, USA [2]Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University,West Lafayette, IN, USA [3]Weldon School of Biomedical Engineering, Purdue University,West Lafayette, IN, USA

出　　处：《Neural Regeneration Research》2014年第11期1093-1095,共3页中国神经再生研究（英文版）

摘　　要：Traumatic brain injury （TBI） and spinal cord injury （SCI） causes significant cell death （Raghupathi et al., 1995; DeKosky et al., 1998; Hall et al., 2005; Farkas and Povlishock, 2007） and tissue lesion in the neocortex （Lighthall et al., 1989; Lyeth et al., 1990）, leaving many patients with substantial motor dis- ability and cognitive impairment （Harem et al., 1992; Scheff et al., 1997）. Unfortunately, at present, there are no clinically demonstrated FDA approved drug therapies for treatment of TBI and SCI patients that reduce the neurological injuries. Thus, TBI and SCI are serious health problems. The devel- opment of therapeutic approaches to prevent neuronal death and enhance neuroregeneration for promoting post-traumat- ic functional recovery would be of enormous clinical, social, and economic benefits. The reviews in this specific issue focus largely on the current progress on diagnosis, neuroprotection, and potential neurorepair with stem cells.Traumatic brain injury （TBI） and spinal cord injury （SCI） causes significant cell death （Raghupathi et al., 1995; DeKosky et al., 1998; Hall et al., 2005; Farkas and Povlishock, 2007） and tissue lesion in the neocortex （Lighthall et al., 1989; Lyeth et al., 1990）, leaving many patients with substantial motor dis- ability and cognitive impairment （Harem et al., 1992; Scheff et al., 1997）. Unfortunately, at present, there are no clinically demonstrated FDA approved drug therapies for treatment of TBI and SCI patients that reduce the neurological injuries. Thus, TBI and SCI are serious health problems. The devel- opment of therapeutic approaches to prevent neuronal death and enhance neuroregeneration for promoting post-traumat- ic functional recovery would be of enormous clinical, social, and economic benefits. The reviews in this specific issue focus largely on the current progress on diagnosis, neuroprotection, and potential neurorepair with stem cells.

关 键 词：TBI NSCS neuroprotection and neurorepair 

分 类 号：R741[医药卫生—神经病学与精神病学]