谷氨酰胺预防及治疗新生儿上消化道出血的疗效观察  

CLINICAL EFFICACY OF GLUTAMINE ON PREVENTION AND TREATMENT OF NEONATE UPPER GASTROINTESTINAL HEMORRHAGE

作　　者：朱本辉 李贵才[2] 谢鹤[2] 

机构地区：[1]广东省潮州市湘桥区凤新社区卫生服务中心儿科,广东潮州521000 [2]广东省潮州市中心医院儿科二病区,广东潮州521000

出　　处：《河北医科大学学报》2014年第7期780-782,共3页Journal of Hebei Medical University

摘　　要：目的：探讨谷氨酰胺预防及治疗新生儿上消化道出血的效果。方法对171例有上消化道出血高危因素的新生儿进行随机抽签分组，治疗组89例应用静脉滴注奥美拉唑加口服谷氨酰胺治疗，对照组82例应用静脉滴注奥美拉唑治疗，比较2组上消化道出血发生率和上消化道出血的止血时间。结果治疗组与对照组上消化道出血发生率差异有统计学意义（χ2＝3.917，P ﹤0.05），上消化道出血患者止血时间差异有统计学意义（ t ＝2.836，P﹤0.05）。结论口服谷氨酰胺可预防上消化道出血，并可促进上消化道出血治愈，而且是安全的。Objective To investigate the effect of glutamine on prevention and treatment of neonate upper gastrointestinal hemorrhage（ UGH）. Methods There were 171 neonates with risk factors for upper digestive tract hemorrhage were randomly grouped,89 cases as treatment group intravenous omeprazole and oral glutamine were given,82 cases as control group intravenous omeprazole given only. The incidence of UGH and the time of UGH between two groups were compared. Results The incidence of upper gastrointestinal bleeding in treatment group and control group showed significant difference （χ2 =3 . 917 ,P﹤0 . 05 ）,gastrointestinal bleeding cases showed significant difference in hemostasia time （ t=2 . 836 ,P﹤0 . 05 ）. Conclusion Oral glutamine has effect both on prevention and treatment of UGH with safety.

关 键 词：上胃肠道 出血 谷氨酰胺 婴儿 新生 

分 类 号：R573.2[医药卫生—消化系统]