肝癌血清标志物研究进展  

Advances in Serum Biomarkers of Hepatocellular Carcinoma Research

作　　者：张爱英[1] 刘秀红[2] 张永宏[2] 赵元顺[2] 金伯旬 刘金花[2] 孙莉波[2] 孙焕芹[2] 李宁[1,2] 

机构地区：[1]首都医科大学附属北京佑安医院北京市肝病研究所,北京100069 [2]首都医科大学附属北京佑安医院,北京100069

出　　处：《现代生物医学进展》2014年第25期4981-4983,共3页Progress in Modern Biomedicine

基　　金：北京市肝病研究所基金(BJIH-01206);首都医科大学重点实验室基金(2013GYGA03);国家国际科技合作专项(S2012ZR0153)

摘　　要：肝癌是全球最常见的恶性肿瘤之一,多数患者确诊时已属中晚期。5年以上长期生存率仅为10%左右。肝癌的早期诊断成为提高患者长期生存率的最佳有效途径。近年来,血清肿瘤分子标志物已经成为肝癌早期诊断研究领域的研究热点之一血清甲胎蛋白(AFP)检测是当前诊断肝癌常用而又重要的方法。对肝癌的确诊、预后推测、疗效判断及复发转移的监测具有良好的临床价值。甲胎蛋白异质体(AFP-L3)和脱α-羧基凝血酶原(DCP)在预测肝癌预后方面可能优于AFP。磷脂酰基醇蛋白聚糖3(GPC-3)和α-L岩藻糖苷酶(AFU)作为AFP的补充,能够大幅提高肝癌诊断的正确率。血管内皮生长因子(VEGF)、胰岛素样生长因子Ⅱ(IGF-Ⅱ)和高尔基Ⅱ型跨膜蛋白(GP-73)过表达发生在肝癌早期,有可能成为肝癌早期诊断指标。凋亡早期蛋白(M30)可以作为监测癌细胞凋亡的重要生物标记。细胞质胸苷激酶(TK1)、肝细胞生长因子(HGF)和CD147抗原分子在多种癌组织包括肝癌中显著高表达。本文对国外近几十年来肝癌血清标志物研究的一些成果进行了总结和评价,以期为国内学者进行此类研究提供一定的借鉴。Hepatocelluler carcinoma is one of the most common forms of cancer around the world, but most of the patients are diagnosed at advanced saps. The five year survival rate is 10 percent. So the diagnosis of hepatocelluler carcinoma becomes effective measurements that can raise the survival rate in the early. The serum biomarkers of hepatocellular carcinoma are currently receiving considerable attention for the earlier diagnosis of hepatocelluler carcinoma. Serum alpha-fetoprotein （AFP） test is one common and important diagnostic method of hepatocelluler carcinoma and also has an applied value for the hepatocelluler carcinoma＇s diagnosis, patient＇s prognosis, judging recurring and shitting and curative effect. AFP-L3 and DCP was superior in diagnosis of patient＇s prognosis to AFP. Combined detection ofAFP, GPC3 and AFU can improve the diagnosis of hepatocelluler carcinoma. VEGF, IGF- II and GP-73 is over-expressed in the early stage of hepatocelluler carcinoma, and they might be a potential biomarker in the early diagnosis of hepatocelluler carcinoma. M30 is an ideal biomarker for monitoring apoptosis of carcinoma cells in blood. It has been shown that in a variety of tumors include hepatocelluler carcinoma, the expression of TK1, HGF and CD 147 is significantly higher. The present paper is a review of the research of serum biomarkers of hepatocellular carcinoma during the last several decades, and it is hoped that this can offer insights for researchers in China in this area.

关 键 词：肝癌 血清标志物 AFP 早期诊断 预后推测 

分 类 号：R735.7[医药卫生—肿瘤]