MicroRNA:潜在的新型食管癌生物标记  

MicroRNA: a New Potential Esophagus Cancer Biomarker

作　　者：付文博[1] 魏育涛[1] 罗波[1] 薛亚军[1] 胡思远[1] 

机构地区：[1]石河子大学医学院第一附属医院心胸外科,新疆石河子832000

出　　处：《现代生物医学进展》2014年第25期4984-4986,4990,共4页Progress in Modern Biomedicine

基　　金：兵团卫生科技基金(2014BB019)

摘　　要：MicroRNA(miRNA)为长约23个核苷酸非编码的内源性微小RNA,在各种调节通路中发挥重要的基因调节作用,主要通过靶向mRNA 3'非翻译端,抑制或降解mRNA,调控细胞发育、凋亡、增殖及分化等生命活动。到目前为止,miRNA为人们理解肿瘤的发生发展提供了新的角度,展示了其作为肿瘤标志物的巨大潜能。食管癌是常见的恶性肿瘤之一,越来越多的证据表明miRNA与食管癌存在密切联系。本文就食管癌的发生发展,病理分类,血清学标记物,耐药性与miRNA表达特点的关系展开论述。MicroRNA （miRNA） are endogenous approximately 23 nucleotide noncoding RNA molecules that play important gene-regulatory roles in diverse regulation pathways, including those involved in cell development, differentiation, proliferation, and apoptosis by targeting mRNAs for cleavage or translational repression. To date, miRNAs have given us a new perspective to understand carcinogenesis and demonstrated the potential role to act as cancer biomarkers. Esophageal cancer is one of the most lethal human cancers in China. Growing evidence has showed a close connection between miRNAs and esophageal cancer. In this review, information regarding the relationship between the esophageal cancer development, pathological classification, plasma marker, chemoresistance and the expression characteristic ofmiRNAs is discussed.

关 键 词：微小RNA 食管癌 诊断 生物标记 

分 类 号：R735.1[医药卫生—肿瘤]