长沙市PM10与脑卒中急诊关系的病例交叉研究  

A Case-Crossover Study on PM10 and Emergency Hospital Visits for Stroke in Changsha

作　　者：何芳[1] 黄志军[2] 周玉庆 李长罗[1] 宋坤[1] 

机构地区：[1]长沙市中心医院,湖南长沙410004 [2]中南大学湘雅三医院,湖南长沙410013 [3]湖南省高血压研究中心,湖南长沙410013

出　　处：《现代生物医学进展》2014年第24期4695-4697,4619,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81202166);中南大学中央高校基本科研业务费专项资金(2012QNZT166);湖南省社会发展支撑计划一般项目(2011FJ4266)

摘　　要：目的:探讨长沙市大气可吸入颗粒物(PM10)与脑卒中急诊的相关性。方法:收集2008-2009年间长沙市每日脑出血和脑梗死急诊数据,同期收集长沙市大气可吸入颗粒物(PM10)及相关气象数据,利用季节分层的单向回顾性1:1配对病例交叉研究设计,建立单污染物模型和多污染物模型进行分析。结果:在调整气温和相对湿度的单污染物滞后模型中,秋季滞后0、1、2天的PM10日均浓度每增加10μg/m3,与脑出血和脑梗死的的OR(95%CI)值分别为0.953(0.871-1.042)和0.970(0.910-1.034)、0.984(0.913-1.061)和0.965(0.902-1.031)、0.996(0.928-1.069)和0.964(0.904-1.029),关联具有统计学意义(P<0.05)。结论:长沙市PM10浓度变化对脑卒中发病有影响。Objective： To investigate the correlation between particulate matters with an aerodynamic diameter of 〈10 μm （PM 10） and emergency hospital visits （EHVs）for stroke in Changsha. Methods： The daily EHVs for stroke were gathered from Changsha central hospital and the third Xiangya hospital during 2008-2009. The corresponding air pollutions, meteorological data were collected. The seasonal-stratified case-crossover design with 1：1 matched pair was used to set up single-pollution models for the data analysis. Results： After adjusting the temperature and relative humidity in single-pollution models, an increase of 10 μg/m3 increase in PM10 were significantly association with EHVs of cerebral hemorrhage and cerebral infarction at lags of 0 day [OR=0.953 （95%CI： 0.871-1.042） and OR=0.970 （95%：0.910-1.034, separately）], lday [OR=0.984 （95%CI： 0.913-1.061） and OR=0.965 （95%：0.902-1.031, separately）] and 2 day [OR=0.996 （95%CI： 0.928-1.069） and OR=0.964 （95%：0.904-1.029, separately）]in autumn. Conclusion： Elevated the concentration of PM10 was associated with increased EHVs for stroke in Changsha.

关 键 词：脑卒中 急诊 可吸入颗粒物 病例交叉研究 

分 类 号：R743[医药卫生—神经病学与精神病学]