Ghrelin对心肌梗死大鼠恶性心律失常和早期左室重构的影响(英文)  

Ghrelin Prevents Malignant Arrhythmia and Early Left Ventricular Remodeling in Rats with Myocardial Infarction

作　　者：栾晓[1] 高胜利[1] 刘虹[2] 逄明杰[2] 祝海[2] 王萍[2] 公衍玲[3] 郭菲菲[1] 孙向荣[1] 徐珞[1] 

机构地区：[1]青岛大学医学院病理生理教研室,山东青岛266021 [2]青岛市立医院,山东青岛266000 [3]青岛科技大学化学工程学院,山东青岛266042

出　　处：《现代生物医学进展》2014年第26期5005-5010,共6页Progress in Modern Biomedicine

基　　金：National Natural Science Foundation of China (31071014;81100260;81270460;81300281);Qingdao Municipal Science and Technology Commission (11-2-3-3-(2)-nsh and 13-1-4-170-jch)~~

摘　　要：目的:本文主要研究ghrelin对心肌梗死大鼠恶性心律失常和早期左室重构的影响。方法:心肌梗死大鼠模型每天两次注射ghrelin(100μg/kg)或生理盐水。通过超声心动图评估大鼠的心脏重量并且观察大鼠的血流动力学。使用酶免疫分析法测定血清胰岛素生长因子I(IGF-1)、血浆肾上腺素、去甲肾上腺素和多巴胺的浓度。注射药物前后分析大鼠的神经功能。结果:与对照组相比,ghrelin治疗的心肌梗死模型大鼠生存率显著增加(P<0.05),心脏功能增强,但心肌梗死面积差异不大(P>0.05)。结论:Ghrelin能够提高心肌梗死模型大鼠的生存率、缓解心肌梗死大鼠心率失常、改善心肌梗死大鼠左心室重构。Objective： To investigate the effects of ghrelin on the cardiovascular system in rats with myocardial infarction （MI）, such as preventing malignant arrhythmia, delaying left ventricular remodeling and decreasing mortality. Methods： Ghrelin （100 μg/kg sc, twice daily） or saline were administered for 2 weeks from the day of MI operation in Wistar rats. The effects of ghrelin on cardiac remodeling were evaluated by echocardiographic and hemodynamic. Serum insulin-like growth factor I （IGF-I）, plasma concentrations of epinephrine, norepinephrine, and dopamine were measured by using enzyme immunoassay kit. Before and after ghrelin （100 μg/kg sc） was administered in conscious rats with MI, the autonomic nervous function was investigated by power spectral analysis obtained by a telemetry system. Results： Results showed that compared with that in the control group rats, the percent survival of ghrelin treated rats increased significantly （P〈 0.05）, the cardiac function enhanced remarkably, but the size of the infarct of the left ventricular wall did not significantly differ between MI ＋ NS rats and MI ＋ Ghrelin rats （P〉 0.05）. Conclusions： Ghrelin can increase the survival rate, improve cardiac arrythmias and alleviate left ventricular remodeling of myocardial infarction rats.

关 键 词：GHRELIN 心肌梗死 左心室重构 心律失常 

分 类 号：R363[医药卫生—病理学]