肠内生态免疫营养对重症急性胰腺炎猪肾损害的影响  

Effect of enteral ecoimmunonutrition on kidney injury of severe acute pancreatitis in pig model

作　　者：田觅 邹晓平 陈磊[2] 魏威[3] 叶静[3] 

机构地区：[1]江苏省南京鼓楼医院消化内科,南京210008 [2]江苏省苏北人民医院消化内科 [3]南京医科大学附属杭州医院胃肠肛外科

出　　处：《南通大学学报（医学版）》2014年第3期159-162,共4页Journal of Nantong University(Medical sciences)

基　　金：国家自然科学基金资助项目(81272742);浙江省医药卫生一般研究计划项目(2012KYB145)

摘　　要：目的 :观察不同营养支持对重症急性胰腺炎(severe acute pancreatitis,SAP)猪的肾损害的影响。方法 :采用胰管内注射牛磺胆酸钠和胰蛋白酶的方法诱导猪SAP模型;将SAP模型动物随机分为3组,分别为肠外营养组(parenteral nutrition,PN)、肠内要素营养组(elemental enteral nutrition,EEN)和肠内免疫微生态营养组(enteral ecoimmunonutrition,EIN),分别进行相应的营养8 d。动态检测各组血尿素氮(blood urea nitrogen,BUN)、肌酐(creatinine,Cr)。营养8 d后剖腹测定肾脏丙二醛(malondialdehyde,MDA)含量及超氧化物歧化酶(supemxidedismutase,SOD)活力,观察肾脏组织病理学改变,进行病理评分。结果:营养支持8 d后,EIN组的BUN、Cr均低于PN组和EEN组(均P<0.05)。营养8 d后,EIN组的肾脏MDA含量及肾脏病理学评分均低于PN组和EEN组,而肾脏SOD活力则明显高于PN组和EEN组(均P<0.05)。结论:早期EIN可减轻SAP时的肾损害。Objective： To evaluate the effect of enteral ecoimmunonutrition（EIN） on kidney injury in pig with severe acute pancreatitis. Methods： Swine model of SAP was induced by injecting 5% sodium taurecholate into the pancreatic duel. The pigs were randomly divided into three groups, parenteral nutrition（PN） group, elemental enteral nutrition（EEN） group, and EIN group after induction of SAP. Each group was treated with abovementioned nutrition supports for eight days , respectively. The serum blood urea nitrogen and creatinine were determined dynamically. All the pigs were sacrificed after the 8-day nutri-tion support, and renal malondialdehyde（MDA）, supemxidedismutase（SOD） were measured. The histopathological changes of kidney were examined. Results： After 8 days of nutrition support, BUN and Cr levels in EIN group were significantly lower than those in TPN group and EEN group（all P〈0.05）. In addition, the renal concentration of MDA and renal histopathological scores were lower than those of PN group and EEN group, while renal SOD activity was higher in EIN group than those in the other 2 groups（P〈0.05）. Conclusion：Early enteral EIN is superior to PN and EEN could alleviate renal injury in SAP.

关 键 词：重症急性胰腺炎 生态免疫营养 肠道营养 胃肠外营养 肾损害 猪 

分 类 号：R576[医药卫生—消化系统]