GC法同时测定利胆排石片中厚朴酚及和厚朴酚含量  

Determination of Magnolol and Honokiol in Lidanpaishi Tablets by GC

作　　者：赵磊[1] 邓莹[2] 李岩[3] 赵兰英[4] 宋玉红[4] 

机构地区：[1]四平市食品药品检验所,吉林四平136000 [2]北华大学药学院,吉林吉林132013 [3]吉林省神经精神病医院,吉林四平136000 [4]吉林师范大学化学学院,吉林四平136000

出　　处：《解放军药学学报》2014年第3期237-238,241,共3页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：吉林省教育厅科技发展计划项目;No.2012177

摘　　要：目的建立利胆排石片中厚朴酚、和厚朴酚的含量测定方法。方法采用GC法，二甲基聚硅氧烷毛细管色谱柱，载气：氮气，检测器：FID。结果回归方程厚朴酚、和厚朴酚分别为Y=94．12x＋11．28，r=0．9999；Y=135X＋18．21，r=0．9999。结果表明，厚朴酚、和厚朴酚分别在0．01482—1．482、0．02103～2．103mg·ml-1范围内具有良好的线性关系。回收率厚朴酚、和厚朴酚分别为99．6％、99．8％，各成分加样回收率均符合要求。结论该方法简便快捷，准确、重复性好，灵敏度高，可用于建立利胆排石片的定量质量标准。Objective To establish an assay standard for Lidanpaishi tablets. Methods GC was used to determine the content of magnolol and honokiol. Crossbond 100% dimethyl polysiloxane capillary chromatographic column was used with nitrogen as the carrier gas and FID as the detector. Results The linear range was range was 0. 014 82 -1. 482 mg 丶ml-1 for magnolol and 0. 021 03 -2. 103 mg 丶ml-1 for honokiol. The recovery met the re- quirement. Conclusion The GC method is simple, accurate and can be used for quality control of Lidanpaishi tab- lets.

关 键 词：利胆排石片 厚朴酚 和厚朴酚 GC 含量测定 

分 类 号：R927.2[医药卫生—药学]