甲状腺乳头状癌合并桥本甲状腺炎的临床病理及预后分析  

Clinical-pathological features and prognosis analysis of papillary thyroid carcinoma with coexistent Hashimoto＇s thyroiditis

作　　者：陈森林[1] 刘胜[1] 吴星刚[1] 包安娜 王春淑[2] 王英[2] 

机构地区：[1]解放军第411医院普外科,上海200081 [2]解放军第411医院病理科,上海200081

出　　处：《临床外科杂志》2014年第6期414-416,共3页Journal of Clinical Surgery

摘　　要：目的：分析甲状腺乳头状癌（PTC）合并桥本甲状腺炎（HT）的临床病理特点及预后。方法回顾性分析我院收治的68例PTC患者的临床特点、病理资料，其中合并HT患者29例，未合并HT患者39例。所有患者均接受药物和手术治疗，比较两组患者的临床和病理特点及预后情况。结果与未合并HT的PTC患者比较，合并HT的PTC患者女性比例明显较大，淋巴结转移明显减少（χ2＝4．41，4．04，P＜0．05）；两组患者在肿瘤病灶、包膜侵犯、甲状腺外侵犯、微小癌、多灶性肿瘤等方面差异均无统计学意义（P＞0．05）；随访期间，合并HT的PTC患者复发率10．3％，未合并HT的PTC患者复发率5．1％（χ2＝0．66，P ＞0．05）。结论 PTC合并HT好发于女性，淋巴结转移相对少，应常规行甲状腺全切加中央区颈部淋巴结清扫。Objective To analyze the clinical pathological features and prognosis of papillary thyroid carcinoma（PTC）with coexistent Hashimoto＇s thyroiditis（HT）.Methods Clinical features and pathological data of 68 PTC patients who were treated in our hospital were retrospectively analyzed.There were 29 cases with coexistent HT（coexistence group）and 39 cases without HT（noncoexistence group）.All the cases were given drugs and surgical treatment,the clinical-pathological features and prognosis were analyzed between the two groups.Result Compared with non-coexistence group,the ratio of female patients increased with decreased lymphatic metastasis in the coexistence group（χ2 =4.41,4.04,P〈0.05）.There were no significant differences on tumor lesions,capsular invasion,extrathyroidal extension,tiny thyroid carcinoma and multifocal tumor be-tween the two groups（P〉0.05）.The recurrence rates in coexistence group and non-coexistence group were 10. 3%and 5.1%（χ2 =0.66,P〉0.05）.Conclusion PTC with coexistent HT mainly occurs in women and it has a relatively low ratio of lymph node metastases.Thyroidectomy and lymph node dissection in the central neck area should be routinely performed.

关 键 词：甲状腺乳头状癌 桥本甲状腺炎 临床病理 预后 

分 类 号：R736.1[医药卫生—肿瘤]