部分脾栓塞联合心得安预防食管胃底静脉曲张再出血的研究  

Study on partial splenic embolization combined with propranolol for preventing rebleeding of esophageal and gastric varices

作　　者：郑仁斌[1] 乐桥良[1] 黄夺夏[1] 沈清玉[1] 

机构地区：[1]福建医科大学附属闽东医院消化内科,福建宁德355000

出　　处：《中国中西医结合消化杂志》2014年第7期390-392,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：[目的]评价部分脾动脉栓塞术(PSE)联合心得安预防食管胃底静脉曲张再出血的临床疗效。[方法]55例食管胃底静脉曲张破裂出血患者,随机分为两组,其中心得安组28例,PSE联合心得安组27例,比较两组患者外周血象变化,门静脉、脾静脉管径变化,以及3个月、6个月、1年、2年不同时间段的再出血率、病死率和并发症情况。[结果]术后1个月PSE联合心得安组较心得安组外周血白细胞及血小板显著升高,门静脉及脾静脉管径明显缩小,再出血率降低,差异有统计学意义(P<0.05)。[结论]PSE联合心得安预防食管胃底静脉曲张再出血较单独使用心得安有更好的疗效。[Objective]To evaluate the efficacy of treatment with partial splenic artery embolization （PSE） combined with propranolol for preventing rebleeding on esophageal and gastric varices.[Methods] Fifity-five patients with esophageal and gastric varices bleeding were randomly divided into two groups,propranolol treatment group （28 cases）,PSE combined with propranolol treatment group （27 cases）.The peripheral blood change,diameter of portal vein and splenic vein change of the two groups were observed.Rebleeding rate,death rate and complication rate were compared after 3 months,6 months,1 year and 2 years.[Results]Compared with the propranolol treatment group,one month after surgery,peripheral blood white cells and platelets increased more significantly,the inner diameters of portal vein and splenic vein was reduced more significantly,and rebleeding rate reduced in PSE plus propranolol group （P＜0.05）.[Conclusion]PSE combined with propranolol treatment has better effect than propranolol treatment in the prevention of esophageal and gastric varices rebleeding.

关 键 词：脾动脉栓塞 心得安 肝硬化 食管胃底静脉曲张 再出血 

分 类 号：R571.3[医药卫生—消化系统]