Efficient and mild cyclization procedures for the synthesis of novel 2-amino-4H-pyran derivatives with potential antitumor activity  

作　　者：Dao-Cai Wang Yong-Mei Xie Chen Fan Shun Yao Hang Song 

机构地区：[1]Department of Pharmaceutical and Biological Engineering,College of Chemical Engineering,Sichuan University [2]State Key Laboratory of Biotherapy,West China Hospital,West China Medical School,Sichuan University

出　　处：《Chinese Chemical Letters》2014年第7期1011-1013,共3页中国化学快报（英文版）

摘　　要：A series of novel 2-amino-4H-pyran derivatives have been synthesized via a three-component reaction of α,β-unsaturated ketone derivatives, malononitrile, aldehydes in excellent yields, using DBU as a catalyst and ethanol as a cheap, safe, and environmentally benign solvent under mild conditions. Their antitumor activity was evaluated in three human tumor cell lines, including human colon cancer （HCT116）, human cervical cancer （Hela）. and non-small cell lung cancer （H1975）.A series of novel 2-amino-4H-pyran derivatives have been synthesized via a three-component reaction of α,β-unsaturated ketone derivatives, malononitrile, aldehydes in excellent yields, using DBU as a catalyst and ethanol as a cheap, safe, and environmentally benign solvent under mild conditions. Their antitumor activity was evaluated in three human tumor cell lines, including human colon cancer （HCT116）, human cervical cancer （Hela）. and non-small cell lung cancer （H1975）.

关 键 词：Synthesis 2-Amino-4H-pyran derivatives MULTICOMPONENT ANTICANCER 

分 类 号：TQ25[化学工程—有机化工]