中医动物模型建立的研究进展及思路  

Research Progress and Research Thoughts of Establishing Chinese Medicine Animal Models

作　　者：旺建伟[1,2] 叶虹玉 胥风华[1] 赵雪莹[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江省中医药基础重点实验室,黑龙江哈尔滨150040

出　　处：《中医药信息》2014年第4期80-84,共5页Information on Traditional Chinese Medicine

基　　金：国家教育部"春晖计划"合作科研项目(No.Z2010021);中国博士后科学基金项目(No.2013M531079);黑龙江省博士后资助项目(No.LBH-Z12246);黑龙江省教育厅科研项目(No.12521502);黑龙江中医药大学优秀创新人才支持计划资助(优秀学术带头人)(No.051217)

摘　　要：中医动物模型研究已有50余年,日渐成熟,并不断的发展和完善,但现今仍然存在着一定的概念混淆、分类模糊,研究思路和造模方法不够明确,评价体系不完善等问题。为辨明中医动物模型由来,对中医动物模型进行了梳理,阐明了中医理论模型、中医实体模型、中医动物模型的区别。同时,为明确中医动物模型的分类,更好的理解中医动物模型的特点,将模型细化为疾病动物模型、证候动物模型、病证结合动物模型,并对其他模型分类进行补充说明。在此基础上,对中医动物模型的研究思路、造模方法进行深入研究总结,为中医动物模型的研究提供方法和依据。中医动物模型因其具有中医理论特色,因此其评价也具有特殊性,可以分为中医一般状态评价和借助西医方法学进行评价。随着科学技术的不断发展,中医动物模型的评价趋于标准化、客观化、规范化。中医动物模型研究的发展迅速,更多的病证结合动物模型在不断的完善,为中医方-证-病深入研究奠定了坚实基础。Research on Chinese medicine animal models has lasted for more than fifty years , which has become gradually mature , progressive development and constant improvement;but there are still some conceptual con-fusions , fuzzy classifications , unclear researching ideas and modeling methods and unimproved evaluative sys-tems .To identify the origin of Chinese medicine animal models and clarify the distinction among Chinese med -icine theoretical models , Chinese medicine physical models and Chinese medicine animal models .Meanwhile , physical models and Chinese medicine animal models , to better understand the characteristics of Chinese med-icine animal models , which have been subdivided into animal disease models , syndrome animal models and animal models of combination of disease and syndrome , that also makes some complementary explanation of other models classifications .On this basis , the article makes a deep conclusion of the idea of Chinese medi-cine animal models and modeling methods to provide a method and basis of the study of Chinese medicine ani -mal models .Because of their theoretical characteristics , Chinese medicine animal model ’ s evaluation also has its particularity , which can be divided into general Chinese medicine evaluation and aiding western methodolo-gy evaluation .With the continuous development of science and technology , the evaluation of Chinese medicine animal models tends to be standardization , objectification and normalization .The quick development of studies in Chinese medicine animal models and the continuous improvement of more diseases and syndrome animal models, those are all lay a solid foundation for Chinese medicine ’ s deep study of diseases and syndromes .

关 键 词：中医动物模型 研究进展 研究思路 模型分类 

分 类 号：R-332[医药卫生]