胎儿早孕期三尖瓣反流对染色体异常的诊断价值  

Value of fetal tricuspid regurgitation in early screening for chromosomal abnormalities

作　　者：韩华[1] 李建玲[1] 常凤玲[1] 杨丹丹[1] 贾松峰[1] 

机构地区：[1]河南省新乡市中心医院超声影像科,453000

出　　处：《实用医学杂志》2014年第14期2273-2275,共3页The Journal of Practical Medicine

摘　　要：目的：探讨胎儿早孕期三尖瓣反流在染色体异常筛查中的临床意义。方法：对1262例孕11～14周胎儿进行染色体异常筛查，所有胎儿行超声检查，观察胎儿生长发育除外严重胎儿畸形。测量头臀长、颈项透明层、三尖瓣频谱等，可疑者进一步行染色体检查。所有胎儿进行随访。结果：接受筛查的1262例孕妇中，共发现三尖瓣反流68例，1239例染色体正常胎儿中，发现三尖瓣反流54例（4．4％），23例染色体异常胎儿中，发现三尖瓣反流14例（61％）。这一超声特征诊断染色体异常敏感性和特异性分别为61％、95％。无论染色体正常与否，共发现先天性心脏畸形胎儿28例。先天性心脏畸形胎儿中三尖瓣反流发生率64％．未合并心脏畸形胎儿者三尖瓣反流发生率为1．5％。结论：三尖瓣反流是孕早期胎儿染色体异常的有效预测指标。Objective To investigate the clinical significance of fetal tricuspid regurgitation （TR） in the screening of chromosomal abnormalities at the first-trimester. Methods Screening for chromosomal abnormalities was carried out in 1 262 fetuses at 11＋0 to 13＋6 weeks. Ultrosound was performed to measure crown rump length and nuchal translucency （NT） thickness, and to acquire tricuspid waveform. All the neonates were followed up for 6 months after birth. Results Among the 1 262 fetuses, 68 were found to have TR. TR was present in 54 （4.4%） of the 1 239 chromosomally normal fetuses, and in 14 （61%） of the 23 with chromosomal abnormalities. Cardiac malformations were detectable in 28 fetuses. The prevalence of TR was 64% in those with cardiac malformations and 1.5% in those without cardiac malformations. Conclusions Tricuspid regurgitation is an effective predictor for the detection of fetal chromosomal abnormalities at the first trimester.

关 键 词：超声检查 胎儿三尖瓣反流 染色体异常 先天性心脏畸形 

分 类 号：R714.5[医药卫生—妇产科学] R445.1[医药卫生—临床医学]