5-氟尿嘧啶-D-氨基葡萄糖衍生物的设计与合成  

Design and synthesis of 5-fluorouracil-D-glucosamine derivatives

作　　者：杨琴[1] 张志荣[1] 

机构地区：[1]四川大学华西药学院 靶向药物与释药系统教育部重点实验室,四川成都610041

出　　处：《华西药学杂志》2014年第4期359-361,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的设计并合成5-氟尿嘧啶-D-氨基葡萄糖衍生物。方法以D-氨基葡萄糖为起始原料,经保护、水解、酯化、叠氮化、还原等反应,所得中间体与5-氟尿嘧啶-1-乙酸酰化,再脱去保护得目标化合物。结果与结论成功制备了5-氟尿嘧啶-D-氨基葡萄糖衍生物,目标化合物经1HNMR、13CNMR和LC-MS确证。OBJECTIVE To design and synthesize 5 - fluorouracil - D - glucosamine derivatives. METHODS D - glucosamine was used by the starting material. It went through protection reaction, hydrolysis reaction, esterification reaction, azide reaction and reduction reaction. The intermediate was obtain, and then racted 5 - fluorouracil - 1 - acetic acid, pass deprotection reaction. The target compound was obtained. RESULTS and CONCLUSION D - glucosamine was successfully modified. 5 - fluorouracil - D - glucosamine derivatives were synthesized. The chemical structure of the target compound was confirmed by 1 HNMR, 13 CNMR and LC - MS.

关 键 词：D-氨基葡萄糖 5-氟尿嘧啶 衍生物 制备 

分 类 号：R914[医药卫生—药物化学]