VEGF-C表达及D2-40标记的微淋巴管密度与宫颈癌淋巴道转移的关系  

Relationship of VEGF-C expression and microlymphatic vessel density in cervical carcinoma and lymphatic metastasis

作　　者：钟守军[1] 刘祥玉[1] 米贤军[1] 段立锋[1] 陈志强[1] 黄永霞[1] 

机构地区：[1]广东省中山市博爱医院病理科,广东中山528400

出　　处：《中国现代医生》2014年第22期74-77,共4页China Modern Doctor

基　　金：广东省中山市第二批科技计划项目(20102C140)

摘　　要：目的探讨血管内皮生长因子C(VEGF-C)表达和D2-40标记的微淋巴管密度(MLVD)与宫颈癌淋巴道转移的关系。方法应用全自动多功能组织病理检测系统检测80例宫颈癌组织中VEGF-C及D2-40表达,对D2-40阳性脉管进行MLVD计数。结果宫颈癌组织中VEGF-C表达明显增高(49/80),而正常宫颈黏膜组织中未见VEGF-C表达;宫颈癌有淋巴结转移组(20/26)VEGF-C表达水平较无转移组(29/54)增高。宫颈癌组织中MLVD较正常黏膜组织增高;有淋巴结转移组MLVD高于无转移组,且宫颈癌组织中VEGF-C表达与MLVD呈正相关。结论 VEGF-C在宫颈癌组织中表达增高及MLVD计数增高与宫颈癌浸润、淋巴道转移等生物学行为密切相关,可作为评估宫颈癌预后的重要生物学指标;VEGF-C可能促进淋巴管新生。Objective To investigate the relationship of the expression of VEGF-C and MLVD with lymphatic metasta- sis in cervical carcinoma. Methods The immunohistochemistry expressions of VEGF-C and D2-40 were detected by the automatic muhifunctional pathology detection system in 80 cases invasive squamous cell carcinoma of the uterine cervix. The MLVD was assayed by D2-40 positive vascular count. Results Expression of VEGF-C was significantly higher levels in cervical carcinoma （49/80）, and there was no expression in normal cervical mucosal tissues. VEGF-C expression in cervical carcinoma with lymph node metastasis （20/26） was significantly higher than those without lymph node matastasis （29/54）. MLVD in cervical carcinoma was significantly higher than those in normal tissues, and MLVD in cervical carcinoma with lymph node metastasis was significantly higher than those without lymph node matastasis. The VEGF-C expression was positively correlated with MLVD in cervical carcinoma. Conclusion The overexpression of VEGF-C and high MLVD are significantly correlated with cervical carcinoma progression and lymph node metastasis, which can be used as an important biological indicate to evaluate the prognosis of cervical cancer; VEGF-C may pro- mote lymphangiogenesis.

关 键 词：VEGF-C 微淋巴管密度 宫颈癌 淋巴道转移 

分 类 号：R739.5[医药卫生—肿瘤]