阿霉素治疗实验性外伤性增生性玻璃体视网膜病变  

Therapeutic effect of adriamycin on the experimental traumatic proliferative vitreoretinopathy

作　　者：孙建国[1] 招志毅[1] 彭燕一[1] 

机构地区：[1]桂林医学院附属医院眼科,广西桂林541001

出　　处：《华夏医学》2014年第4期41-43,共3页Acta Medicinae Sinica

基　　金：广西自然科学基金资助(桂科自0640191)

摘　　要：目的:观察玻璃体腔注射阿霉素治疗外伤性增生性玻璃体视网膜病变(proliferative vitreoretinopathy,PVR)的效果;同时观察玻璃体腔细胞因子含量的变化。方法:建立外伤性PVR动物模型。随机分为生理盐水组、阿霉素组。直接眼底镜观察PVR程度;酶联免疫吸附法(enzyme-liked immunosorbent assay,ELIsA)测定玻璃体腔白介素-lβ(Interleukin-lβ,IL-lβ)、转化生长因子βl(transforming growth factor-beta 1,TGF-β1)浓度。结果:阿霉素组PVR程度、玻璃体腔IL-lβ浓度、转化生长因子βl浓度低于生理盐水组。结论:玻璃体腔注射阿霉素可以降低外伤性PVR程度,同时下调玻璃体腔IL-lβ、TGF-βl浓度。Objective： To observe the therapeutic effect of the intravitreal injection of adrimycin on the experimental traumatic proliferative vitreoretinopathy（PRV）, and the concentranon changes of cytokines in the vitreous cavity. Methods. ＇ Animal models of traumatic PVR were established, which were randomized into the normal saline group（NS group） and adriamyein group. The degrees of proliferative vitreoretinopathy were estimated by direct ophthalmoscope examination; the concentration of IL-1βand TGF-β1in the vitreous cavity was detected by enzyme-liked immun0sorbent assay（ELIsA）. Results= The degree of PRV, concentration of IL-lβ and TGF-β1, in the vitreous cavity in the adriamycin group are lower than that of the NS group. Conclusion：The intravitreal in jection of adriamycin can decrease the degrees of PVR and the concentration of IL-1β and TGF-β1.

关 键 词：外伤 增生性玻璃体视网膜病变 阿霉素 

分 类 号：R779.1[医药卫生—眼科]