尤瑞克林联合依达拉奉治疗急性脑梗死的Meta分析  

Urinary Kallidinogenase Combined with Edaravone for Treatment of Acute Cerebral Infarction:A Meta-analysis

作　　者：任全维 刘瑞珍[2] 

机构地区：[1]山西医科大学 [2]山西医科大学第二医院

出　　处：《中西医结合心脑血管病杂志》2014年第7期842-845,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的评价尤瑞克林联合依达拉奉治疗急性脑梗死的疗效。方法计算机检索中国学术期刊全文数据库(CNKI)、PubMed数据库、万方数据库、维普期刊资源数据库2009年1月—2013年9月,使用尤瑞克林联合依达拉奉治疗急性脑梗死的随机对照试验(RCT),采用Stata12.0软件进行Meta分析。结果共检出30篇符合标准的RCT文献,共纳入11个随机对照试验,合计828例患者,联合用药组414例,标准对照组414例,Meta分析结果显示:尤瑞克林联合依达拉奉治疗急性脑梗死有效率与常规治疗比较,其差异有统计学意义(P<0.001),OR值,95%CI为4.00(2.62,6.11)。结论与常规治疗相比,尤瑞克林联合依达拉奉治疗急性脑梗死在改善症状、降低病残率、促进神经功能恢复方面疗效明显。To assess the efficacy of urinary kallidinogenase combined with edaravone on acute cerebral infarction.Meth-ods We searched the China National Knowledge Infrastructure,PubMed,Wanfang Data,and VIP,which were all last searched Sep-tember 2013.Randomized controlled trials （RCTs）about urinary kallidinogenase combined with edaravone on acute ischemic stroke were included.Meta analysis was carried out by software Stata 12.0.Results Thirty trials were included,but only eleven trials in-volving 828 patients were assessed.Meta analysis showed：Compared with the union treated group,the difference of the total effec-tive rate was significant [（P〈0.001,OR=4.00,95%CI（2.62,6.11）].Conclusion Compared with routine therapeutic method,uri-nary kallidinogenase combined with edaravone for acute cerebral infarction had better efficacy on reducing neurological impairment,re-ducing the rate of illness,and improving the outcomes.

关 键 词：急性脑梗死 尤瑞克林 依达拉奉 

分 类 号：R743.3[医药卫生—神经病学与精神病学]