P16基因表达与宫颈癌预后相关性分析  

Expression and prognosis significance of P16 in cervical cancer

作　　者：陈悦[1] 张晓薇[1] 邓志校[1] 谭伟坚[1] 黄晓军[1] 范良生[1] 

机构地区：[1]广州医科大学附属第一医院妇产科,510120

出　　处：《实用医学杂志》2014年第15期2417-2420,共4页The Journal of Practical Medicine

摘　　要：目的:通过检测P16基因在宫颈癌中的表达,分析P16基因与宫颈癌预后的关系,评价P16基因在宫颈癌预后预测中的价值。方法:采用免疫组织化学SP法检测P16基因在74例宫颈癌患者组织中的表达,并对P16基因表达与宫颈癌预后的关系进行相关性分析。结果:74例宫颈癌病例中,P16基因的表达阳性率为85%(63/74),P16基因阳性表达与宫颈癌预后呈正相关(P=0.041)。P16基因阳性表达组2年累积生存率为85.2%,P16基因阴性表达组2年累积生存率为100%。P16基因阳性表达组2年累积生存率低于P16基因阴性表达组(P=0.043),两者比较有统计学意义。P16基因阳性表达与临床分期、间质浸润及LVSI呈正相关(P<0.05),而与TNM及组织分化无相关性(P>0.05)。结论:P16基因的阳性表达与宫颈癌患者的预后密切相关,可作为预测宫颈癌预后的指标之一。Objective To access the expression of germ P16 in cervical cancer patients , find out the connection between with the expression in germ of P16 and the prognosis of cervical cancer, and discuss whether P16 can role as an indicator to predict the prognosis. Methods The pathological sections of all 74 cases were tested for the presence of P16 germ, using an immunohistochemistry technique. And the results were analyzed to investigate the value of P16 on the prediction of prognosis of cervical cancer. Results Of all 74 cervical cancer cases, there are 63 cases show positive expression of P16, with the positive expression rate of 85% （63/74）. The positive expression of gene P16 is associated with the prognosis of cervical cancer （P = 0.041 ）. The cumulative survival rate for two years of the positive expression set is 85.2%, and the negative set 100%, which is statistically significant （P = 0.043）. Positiveexpression of P16 is closely related （P 〈 0.05） with clinical stages LVSI and interstitial infihrates, but is irrelevant （P 〉 0.05） with TNM and histological differentiation. Conclusions We suggest that the expression of germ P16 is closely connected prognosis in cervical cancer, and it might be used as one of indicator to predict the prognosis of cervical cancer.

关 键 词：宫颈肿瘤 P16基因 预后 

分 类 号：R737.33[医药卫生—肿瘤]