高敏C反应蛋白与急性脑梗死患者病情严重程度相关性研究  

THE RELATIONSHIP BETWEEN HS-CRP AND THE SEVERITY OF ACUTE CEREBRAL INFARCTION

作　　者：王艳[1] 赵晓晶[1] 陈瑞英[1] 高素玲[1] 安雅臣[1] 彭延波[1] 常丽莎[1] 张江[1] 张艳淑[1] 王大力[1] 

机构地区：[1]河北联合大学附属医院神经内科,河北省唐山市063000

出　　处：《中国煤炭工业医学杂志》2014年第8期1263-1265,共3页Chinese Journal of Coal Industry Medicine

基　　金：唐山市科技局指令计划项目(09130202A-3-25)

摘　　要：目的探讨急性脑梗死患者入院早期高敏C反应蛋白(hs-CRP)与临床病情严重程度的关系。方法连续收集发病时间<24h急性脑梗死患者272例,应用自制调查表收集研究对象的基本信息和疾病史,检测入院后24h内hs-CRP水平,同时收集患者入院后1,7,14d的NIHSS评分、mRS评分作为患者临床病情严重程度的综合判定指标。应用相关分析进行hs-CRP与NIHSS评分、mRS评分的相关性分析,多因素Logistic逐步回归分析找出影响患者7dNIHSS评分、mRS评分的独立危险因素。结果 hsCRP与入院后1,7,14dNIHSS评分,入院后1,7,14dmRS评分高度相关(P<0.001)。hs-CRP是影响7dNIHSS评分及mRS评分的共同危险因子。结论 hs-CRP是急性脑梗死病情危重的独立危险因子。Objective To explore the relationship between the high- sensitivity C - reactive protein （hs - CRP） and the acute cerebral infarction. Methods A sample of 272 patients with acute cerebral infarction patients （onset 〈 24 hoursl were enrolled as our subjects. A selfmade questionnaire was used to collect the basic information and disease history of the patients, the hs - CRP level was detected in 24 hours after admission. At the same time, the NIHSS score and the mRS score of patients who were admitted to hospital after 1 day, 7 days, 14 clays were performed, which were served as the severity of clinical disease comprehensive index. Regression analysis was applied to analyze the relationship between the hs - CRP and the NIHSS score and the mRS score. Multiple factors Logistic stepwise regression analysis was used to look for the independent risk factors which influenced the NIHSS score and the mRS score of seventh day. Re- suits The hs - CRP and the NIHSS score of 1 day, 7 days, 14 days after admission, and the mRS score of 1 day, 7 days, 14 days after admission were highly correlated （ P〈0. 001 ）. Hs - CRP was the common risk factors which influenced the NIHSS score and the mRS score of 7 days. Conclusion The hs - CRP is an independent risk factor of acute cerebral infarction in a critical condition.

关 键 词：高敏C反应蛋白质 NIHSS评分 mRS评分 急性脑梗死 

分 类 号：R743[医药卫生—神经病学与精神病学]