布托啡诺术后自控静脉镇痛对血清TNF-α、IL-6的影响  

Effects of Postoperative Patient-Controlled Intravenous Analgesia with Butorphanol on Serum Levels of TNF-α,IL-6

作　　者：黎阳[1] 钱卫[1] 杜学柯[1] 彭丹晖[1] 裴圣林[1] 陈肖东[1] 潘灵辉[1] 黄冰[1] 

机构地区：[1]广西医科大学附属肿瘤医院麻醉科,南宁市530021

出　　处：《广西医学》2014年第9期1212-1214,共3页Guangxi Medical Journal

基　　金：广西自然科学基金资助项目(0640157)

摘　　要：目的观察腹部手术病人术后布托啡诺、吗啡自控静脉镇痛(PCIA)对血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平的影响。方法择期腹部手术患者30例,按随机数字表法分为布托啡诺组(A组)、吗啡组(B组)和对照组(C组),每组10例。术毕A组、B组行自控静脉镇痛(PCIA),C组在患者需求时给予肌注吗啡10 mg。3组分别于麻醉诱导前(T0)、术后12 h(T1)、24 h(T2)、36 h(T3)、48 h(T4)采集外周静脉血,采用酶联免疫吸附测定法测定血清中TNF-α、IL-6水平。结果 A组、B组T1、T2、T3、T4各时点TNF-α和IL-6水平均低于C组(P<0.05)。结论布托啡诺和吗啡PCIA能抑制术后患者血清TNF-α、IL-6水平的升高。Objective To observe the impacts of patient-controlled intravenous analgesia（ PCIA） with butorphanol and morphine on the serum levels of tumor necrosis factor α（ TNF-α） and interleukin 6（ IL-6） in the patients after abdominal operation. Methods Thirty patients undergoing selective abdominal operation were randomly divided into three groups： butorphanol group（ group A）,morphine group（ group B） and control group（ group C）,with 10 cases in each group. The patients from group A and group B were given PCIA,whereas patients from group C were intramuscularly injected with 10 mg of morphine when necessary. Peripheral venous blood samples were collected at 5 different time points of pre-anesthesia induction（ T0）,12 hours（ T1）,24 hours（ T2）,36 hours（ T3） and 48 hours（ T4） after operation.The levels of TNF-α and IL-6 in serum were measured by enzyme-linked immunosorbent assay（ ELISA）. Results The levels of TNF-α and IL-6 at T1,T2,T3,T4 of group A and group B were significantly lower than those of group C（ P〈0. 05）.Conclusion PCIA with butorphanol and morphine could effectively suppress the increase of serum levels of TNF-α and IL-6.

关 键 词：镇痛 布托啡诺 吗啡 自控静脉镇痛 白细胞介素-6 肿瘤坏死因子-Α 

分 类 号：R246.233[医药卫生—针灸推拿学]