血管内皮生长因子A在食管鳞状细胞癌中的表达及临床意义  

Expression and Clinical Significance of Vascular Endothelial Growth Factor A in Esophageal Squamous Cell Carcinoma

作　　者：马俊[1] 缪蓉[2] 鲁建军[1] 张希[3] 巫国勇[1] 

机构地区：[1]中山大学附属第一医院胸外科,广州市510080 [2]中山大学附属第一医院手术室,广州市510080 [3]中山大学附属第一医院心外科,广州市510080

出　　处：《广西医学》2014年第9期1253-1255,共3页Guangxi Medical Journal

摘　　要：目的探讨食管鳞状细胞癌中血管内皮生长因子A(VEGF-A)的表达及临床意义。方法 60例食管鳞状细胞癌患者,应用免疫组织化学法检测肿瘤组织及其癌旁组织VEGF-A表达、微血管密度(MVD)及微淋巴管密度(MLVD),分析VEGF-A表达与食管鳞癌患者临床病理资料、MVD及MLVD的关系。结果食管鳞状细胞癌组织VEGF-A表达阳性率、光密度值均明显高于正常食管组织(P均<0.05);VEGF-A光密度值在食管癌患者不同临床分期、浸润深度比较,差异有统计学意义(P均<0.05),临床Ⅲ期、浸润深度T3期食管癌患者VEGF-A光密度值较高;VEGF-A表达阳性组患者MVD密度高于阴性组患者(P<0.05)。结论 VEGF-A在食管鳞状细胞癌组织呈高表达,可以指导判断临床分期与浸润深度。Objective To investigate the expression and clinical significance of vascular endothelial growth factor A（ VEGF-A） in esophageal squamous cell carcinoma. Methods Sixty patients with esophageal squamous cell carcinoma were detected for the expression of VEGF-A,microvessel density（ MVD） and microlymphatic vessel density（ MLVD） in tumor tissues and their adjacent tissues by immunohistochemistry,the relationship of VEGF-A expression with clinical pathological data,MVD and MLVD of patients with esophageal squamous cell carcinoma was analyzed.Results The positive rate of VEGF-A expression,optical density in esophageal squamous cell carcinoma tissues were significantly higher than those in normal esophageal tissues（ all P〈0. 05）. There was no significant difference in the VEGF-A optical density among patients with esophageal cancer of different clinical stages or different depths of invasion（ all P〈0.05）. The patients with esophageal cancer of clinical stage Ⅲ and depth of invasion of T3 stage showed a higher VEGF-A light density. The MVD of patients with positive VEGF-A expression was higher than that of patients with negative VEGF-A expression（ P〈0. 05）. Conclusion The high expression of VEGF-A is observed in esophageal squamous cell carcinoma tissues,which might provide a guidance for the judgment of clinical stage and depth of invasion.

关 键 词：食管鳞状细胞癌 血管内皮生长因子A 微血管密度 微淋巴管密度 

分 类 号：R735.1[医药卫生—肿瘤]