XPD基因多态性与非霍奇金淋巴瘤的相关性  

Correlation between XPD genetic polymorphism and non-Hodgkin's lymphoma

作　　者：李素霞[1] 朱宏丽[1] 郭搏[1] 杨洋[1] 王红艳[2] 孙敬芬[2] 曹永彬[3] 

机构地区：[1]解放军总医院老年血液科,北京100853 [2]解放军总医院血液科,北京100853 [3]解放军总医院第一附属医院血液科,北京100048

出　　处：《解放军医学院学报》2014年第8期853-857,共5页Academic Journal of Chinese PLA Medical School

基　　金："重大新药创制"科技重大专项(2008ZXJ09001-019);解放军总医院南楼青年创新基金(NQ201107)~~

摘　　要：目的探讨核苷酸剪切修复基因-着色性干皮病基因D(Xeroderma pigmenting group D,XPD)单核苷酸多态性与非霍奇金淋巴瘤(non-Hodgkin lymphoma,NHL)及其亚型发病风险的关系。方法选取解放军总医院、解放军总医院第一附属医院2011年3月-2013年9月282例NHL患者和231例正常对照者为研究对象,采用SNaPshot方法检测XPD的2个基因rs1799793、rs13181的基因多态性,分析其在NHL组和正常对照组中基因型和等位基因频率分布的差异。采用Logistic回归分析计算各个SNP的等位基因的比值比(odd ratio,OR)和95%置信区间(confidence interval,CI)。结果 XPD rs1799793、rs13181在NHL组和正常对照组中基因型和等位基因频率分布无统计学差异。XPD rs1799793、rs13181组合基因型在对照组和NHL组中无统计学差异。对NHL亚型分析显示,与对照相比较,弥漫大B细胞性淋巴瘤、滤泡性淋巴瘤、T细胞性淋巴瘤、其他B细胞性淋巴瘤发病风险无差异。结论本组人群XPD rs1799793、rs13181基因多态性与NHL组及其亚型的发病无明显相关性。Objective To explore the correlation between Xeroderma pigmenting group D （XPD）gene polymorphisms and non- Hodgkin lymphoma （NHL） risk. Methods A case-control study with 282 non-Hodgkin lymphoma patients and 231 control subjects were conducted to investigate the role of two XPD gene polymorphisms （rs1799793, rs13181） on susceptibility to non-Hodgkin lymphoma by SNaPshot. All statistical analysis were done with R software. Genotype and allele frequencies of XPD were compared between patients and control group by chi-square test. Crude and adjusted odds ratios and 95% confidence intervals were calculated by logistic regression based on genetic different models. Results There was no significant difference between the control group and NHL or NHL subtype cases in genotype and variant genotype frequency. Analysis of XPD rs1799793, rs13181 showed that no combined genotype was associated with risk of NHL overall or four kinds of subtypes of NHL. Conclusion There is no close relationshil3 between XPD polymorphism （rs 1799793, rs 13181） and the risk of NI-IL or each histologic subtype of NHL.

关 键 词：着色性干皮病基因D 非霍奇金淋巴瘤 单核苷酸多态性 

分 类 号：R733.1[医药卫生—肿瘤]