癫痫发病机制的研究进展  

Advances in research of pathogenesis of epilepsy

作　　者：路蝉伊[1] 刘立雄[1] 张云峰[1] 

机构地区：[1]温州医科大学附属眼视光医院,浙江温州325027

出　　处：《解放军医学院学报》2014年第8期876-880,F0003,共6页Academic Journal of Chinese PLA Medical School

基　　金：国家自然科学基金项目(81301117);温州市科技计划项目(Y20140049;Y20140139)~~

摘　　要：癫痫是神经系统常见疾病之一,其发病机制非常复杂,迄今尚未完全阐明。近年来的研究表明,癫痫发作时大脑神经元的异常放电与神经递质、离子通道、神经胶质细胞、突触联系、遗传及免疫等的异常有密切关系。本文就以上方面对癫痫发生机制的研究进展进行综述,以便深入理解癫痫发病机制,为诊断、预防与治疗提供必要的理论依据。Epilepsy is one of the common diseases in the nervous system with its complicated pathogenesis still remained unknown. Recent studies showed that the abnormal discharge from neurons at the onset of epilepsy is closely related with the abnormality of neurotransmitter, ion channel, glial cells, synapse, genetic and immune factors. Following is a review of the advances in path ogenesis of epilepsy in order to provide the theoretical evidence for the diagnosis, prevention and treatment of epilepsy.

关 键 词：癫痫 发病机制 神经递质 离子通道 突触联系 

分 类 号：R742.1[医药卫生—神经病学与精神病学]