抑郁症与单纯型精神分裂症鉴别诊断中定量脑电图的应用价值研究  

Application Value of Quantitative Electroencephalography in Differential Diagnosis between Simple Schizophrenia and Depression

作　　者：顾君[1] 徐清[1] 刘晓伟[1] 季萍[1] 

机构地区：[1]江苏省无锡市精神卫生中心老年精神科,214151

出　　处：《中国全科医学》2014年第20期2312-2316,共5页Chinese General Practice

摘　　要：目的探讨抑郁症、单纯型精神分裂症定量脑电图（QEEG）指标的差异，分析QEEG对两种疾病的鉴别诊断价值。方法选取2012年10月—2013年5月无锡市精神卫生中心门诊及收治的住院抑郁症和单纯型精神分裂症患者，各30例，分别作为抑郁症组和单纯型精神分裂症组；另选取同期在无锡市精神卫生中心体检健康者30例（对照组）。三组受试者均行QEEG检测。脑电图频段划分为：δ（0．8—4．0Hz）、θ（4．0～7．8Hz）、α（7．8—12．8Hz）、β（13．0—20．0Hz）。比较三组δ、θ、α、β频段FP1、FP2、F3、F4、F7、F8、T3、T4、T5、T6、C3、CA、P3、P4、O1、O2的功率值。结果三组δ频段FP1、FP2、F3、F4、F7、F8、T3、C3、C4、P3、P4、O1、O2功率值比较，差异均有统计学意义（P〈0．05），其中单纯型精神分裂症组δ频段FP1、FP2、F3、F4、F7、F8、T3、C3、C4、P3、P4、O1、O2功率值高于对照组，抑郁症组δ频段FP1、FP2、F4、C3、CA、P4、O2高于对照组，单纯型精神分裂症组δ频段FP1、FP2、F3、F7高于抑郁症组（P〈0．05）。三组θ频段F3、F7、F8、P4、O2功率值比较，差异均有统计学意义（P〈0．05），其中单纯型精神分裂症组θ频段F3、F7、F8、P4、O2功率值高于对照组，抑郁症组θ频段F8功率值高于对照组（P〈0．05）。三组仅频段FP1、FP2、F3、F4、F7、F8、T3、T4、T5功率值比较，差异均有统计学意义（P〈0．05），其中单纯型精神分裂症组仅频段FP1、FP2、F3、F4、F7、T3、T4、T5功率值低于对照组，抑郁症组α频段FP2、F4、F8功率值低于对照组（P〈0．05）。三组β频段FP1、FP2、F3、F4、F7、F8、O2功率值比较，差异均有统计学意义（P〈0．05），其中单纯型精神分裂症组β频段FP1、FP2、F3、F4、O2功率值高于对照组，抑郁症组β频段FP1、FP2、F3、F4、F7、F8功率值高于对照组（P〈0．05）。结论抑郁症与单纯�Objective To explore the difference of quantitative electroencephalography （QEEG） wave frequencies of simple schizophrenia （SS） and depression. Methods From October 2012 to May 2013, in Wuxi Mental Health Center, 30 depression patients（ DP group）,30 SS patients（ SS group）,30 healthy subjects（ control group） were included in this study. The 3 groups had QEEG testing. The EEG frequency bands were divided intoδ（0.8-4.0 Hz）,θ（4.0-7.8 Hz）,α（7.8-12.8 Hz）,β（13.0-20.0 Hz）. We compared the wave band powers of δ,θ,α,β frequency bands FP1,FP2,F3, F4,F7,F8,T3,T4,T5,T6,C3,C4,P3,P4,O1,O2 among 3 groups.Results There was significant difference in the wave band power of δ frequency bands FP1,FP2,F3,F4,F7,F8,T3,C3,C4,P3,P4,O1,O2（P ﹤0.05）, higher in SS group than in control group,those of FP1,FP2,F4,C3,C4,P4,O2 higher in DP group than in control group, those of FP1,FP2,F3,F7 higher in SS group than in DP group（P﹤0.05）. There was significant difference in the wave band powers of θ frequency band F3,F7,F8,P4,O2 among 3 groups（P﹤0.05）,those of F3,F7,F8,P4,O2 higher in SS group than in control group,that of F8 higher in DP group than in control group（P﹤0.05）. There was difference in the wave band powers of α frequency band FP1,FP2,F3,F4,F7,F8,T3,T4,T5 among 3 groups（P ﹤0.05）,those of FP1,FP2,F3,F4,F7,T3,T4,T5 lower in SS group than in control group,those of FP2,F4,F8 lower in DP group than in con-trol group（P﹤0.05）. There was difference in the wave band powers of β frequency band FP1,FP2,F3,F4,F7,F8,O2 among 3 groups（P﹤0.05）,those of FP1,FP2,F3,F4,O2 higher in SS group than in control group,those of FP1,FP2, F3,F4,F7,F8higherinDPgroupthanincontrolgroup（P﹤0.05）. Conclusion There is obvious difference in QEEG indicators between patients with depression, SS. QEEG is of great value in differential diagnosis of depression and SS.

关 键 词：抑郁症 精神分裂症 定量脑电图 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R749.42[医药卫生—临床医学]