脑胶质瘤术后放疗联合替莫唑胺化疗同步与序贯治疗的对比  

Contrast research of radiotherapy combined with synchronizing chemotherapy and sequential chemotherapy of temozolomide after glioma surgery

作　　者：刘培杰 申风乾 张燕 高岭 李宁 徐志巧 

机构地区：[1]河南开封市中心医院肿瘤科,开封475000

出　　处：《中国实用神经疾病杂志》2014年第14期23-25,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨脑胶质瘤术后放疗联合替莫唑胺化疗同步与序贯疗法治疗的临床效果。方法将我院收治的46例脑胶质瘤术后患者,随机分为对照组和观察组。对照组采用放疗联合替莫唑胺序贯疗法治疗,观察组采用放疗联合替莫唑胺同步疗法治疗。比较2组无病生存期、治疗过程中不良反应发生情况。结果观察组无病生存期显著长于对照组,差异有统计学意义(P<0.05)。2组不良反应发生率经统计学分析,差异无统计学意义(P>0.05)。结论同步放化疗可显著延长患者的无病生存期,不增加不良反应,为脑胶质瘤术后较好的治疗方案。Objective To study the clinical effect of the radiotherapy combined with synchronizing chemotherapy or se-quential chemotherapy of temozolomide after glioma surgery.Methods 46 patients after glioma surgery were randomly divided into control group and observation group. Control group adopted radiotherapy combined with temozolomide sequential therapy , observation group adopted radiotherapy combined with temozolomide synchronizing therapy. disease free survival time ,adverse reactions of two groups were compared in the process of treatment.Results free survival time of observation group were signif-icantly longer than that of control group ,the difference was statistically significant （P〈0.05）. There was no significant differ-ence in incidence of adverse reactions of two groups ,（P〉0.05）.Conclusion concurrent chemoradiotherapy can significantly prolong the disease free survival time of patients with cerebral gliomas after surgery ,without increasing side effects ,it’s a bet-ter treatment for glioma surgery.

关 键 词：脑胶质瘤 放疗 无病生存期 替莫唑胺 同步 序贯 

分 类 号：R739.41[医药卫生—肿瘤]