尼莫地平对老年慢性脑供血不足患者认知功能及脑血流的影响  

Effects of nimodipine on cognitive function and cerebral blood flow in elderly patients with chronic cerebral circulation insufficiency

作　　者：艾池波 王用兵 

机构地区：[1]重庆市云阳县人民医院神经内科,云阳404500

出　　处：《中国实用神经疾病杂志》2014年第15期14-16,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨尼莫地平对老年慢性脑供血不足(CCCI)患者认知功能及脑血流的影响。方法 60例老年CCCI患者随机分为2组,对照组予阿司匹林、他汀类药物等对症治疗,观察组在此基础上加用尼莫地平片,观察治疗前后患者认知功能及脑血流的变化。结果治疗后观察组患者MMSE及MoCA总分均较治疗前显著改善,且明显优于对照组,差异均有统计学意义(P<0.05);治疗后双侧大脑中动脉MCAVs、MCAVm均较治疗前明显升高(P<0.05),双侧大脑中动脉PI较治疗前明显下降(P<0.05)。结论尼莫地平治疗老年CCCI可扩张脑血管,改善脑血流量,改善认知功能,且用药安全性好。Objective To investigate the effects of nimodipine on cognitive function and cerebral blood flow in elderly patients with chronic cerebral circulation insufficiency （CCCI）. Methods Sixty elderly patients with CCCI were randomly divided into two groups, the control group was treated with conventional therapy, and the observation group was treated with nimodipine tablets based on conventional therapy, the cognitive function and cerebral blood flow changes were compared before and after treatment. Results After treatment, the MMSE and MoCA scores in the observation group were significantly improved compared with those before treatment, and were significantly better than those of the control group, the differences were statis- tically significant （P〈0.05） MCA Vs, MCA Vm of the bilateral middle cerebral artery were significantly higher than those before treatment （P〈0.05）, and PI was more obviously decreased than that before treatment （P〈0.05）. Conclusion The nimodipine treatment in CCCI can dilate cerebral blood vessels, and improve cerebral blood flow and cognitive function, and it is safe.

关 键 词：尼莫地平 慢性脑供血不足 认知功能 经颅多普勒 

分 类 号：R743.32[医药卫生—神经病学与精神病学]