血清肿瘤标记物联合检测在乳腺癌诊断中的临床意义  

The Clinical Significance of Combined Detection of Serum Tumor Markers in the Diagnosis of Breast Cancer

作　　者：彭燕燕[1] 张丹方[1] 肖亮生[1] 陈乐川[1] 

机构地区：[1]汕头市中心医院检验科,广东汕头515054

出　　处：《中外医疗》2014年第19期178-179,共2页China & Foreign Medical Treatment

摘　　要：目的探讨血清肿瘤标记物糖类蛋白抗原153(CAl53)和癌胚抗原(CEA)联合检测在乳腺癌诊断中的临床意义。方法选取乳腺癌患者60例,良性乳腺疾病患者60例,医院内健康人群60例。将3组病例分别编组为观察组、良性对照组和健康对照组。清晨抽取空腹静脉血,离心提取血清。检测CA153及CEA采用化学发光法。结果 CA153和CEA对乳腺癌的敏感性为68.6%和21.0%,特异性为90.8%、和91.0%。联合检测观察组的敏感性为89.7%,联合检测较单项检测相比,联合检测敏感性显著提高,特异性也达到87.5%。结论血清肿瘤标记物联合检测较单项检测在乳腺癌诊断中效果明显,具有重要临床意义。Objective To investigate the clinical significance of combined detection of serum tumor marker carbohydrate antigen 153 （CAl53） and carcinoembryonic antigen （CEA） in the diagnosis of breast cancer. Methods 60 cases of patients with breast cancer, 60 cases of patients with benign breast disease, and 60 cases of healthy people in the hospital were selected and divided into the observation group, the benign group and the healthy controls. Fasting venous blood was drawn in the morning and the serum was extracted by centrifugation. CA153 and CEA were detected by chemiluminescence method. Results The sensitivity of CA153 and CEA for breast cancer was 68.6% and 21.0%, the specificity was 90.8%, and 91.0%, respectively. The combined detection sensitivity of the observation group was 89.7%, compared with the single detection, the combined detection sensitivity was significantly higher, and the combined detection specificity reached 87.5%. Conclusion Compared with the single detection, the effect of combined detection of serum tumor markers in the diagnosis of breast cancer is more obvious with important clinical significance.

关 键 词：CA153 CEA 乳腺癌 

分 类 号：R734.2[医药卫生—肿瘤]