颈椎椎管内原始神经外胚层肿瘤一例并文献复习  

Case report of cervical intraspinal primitive neuroectodermal tumor and literature review

作　　者：王忠[1] 冯勇[1] 戚建军[1] 苏宁[1] 张晓军[1] 张仲[1] 

机构地区：[1]内蒙古自治区医院神经外科,呼和浩特010017

出　　处：《中国综合临床》2014年第8期813-816,共4页Clinical Medicine of China

基　　金：内蒙古自治区科技计划项目（20100501）

摘　　要：目的探讨椎管内的原始神经外胚层肿瘤（PNET）的临床特点。方法回顾性分析1例PNET患者的病历资料，患者女36岁，右上肢及背部疼痛、麻木6个月余，颈椎MRI示C5.7脊髓腹侧硬膜下梭形占位，不均匀强化，手术及病理证实为PNET，结合文献分析其临床特点。结果手术近全切除肿瘤并减压，术后病理及免疫组化证实为椎管内PNET，术后放射治疗，术后3个月复查MRI示肿瘤原位复发。结论椎管内的PNET是一种罕见椎管内肿瘤，预后差，病理学检查是诊断的依据。最佳的治疗还没有被定义，手术切除及术后放化疗同步，或单纯放疗，可能会取得好的疗效，多学科综合治疗的标准需要进一步的临床研究。Objective To investigate the clinical characters and therapy of primitive neuroectodermal tumor（PNET）. Methods A retrospective analysis was conducted. A 36-year-old female patient was showed pain and numbness of the right upper limb and back for 6 months. The cervical spine MRI showed a spindle- shaped intradural mass right ventrolateral of spinal cord at C5-7 with in homogeneously enhancing. Surgery and pathologic examination confirmed that was PNET. Combiled with a series of literatures to analyse the clinical characters Results Surgery was performed to remove the tumor and decompression combined with radiotherapy. The pathologic examination and immunohistochemical analysis revealed that it was PNET. MRI identified local recurrence in spinal canal at 3 month later after surgery. Conclusion Spinal PNET is an uncommon intraspinal tumor with poor prognosis. Histopathology is the evidence of diagnosis. Optimal therapy has not yet been found. Surgical resection with the combination of chemo-radiotherapy or radiotherapy might get the better outcomes. Muhidisciplinary treatment should be further clinical required.

关 键 词：原始神经外胚层肿瘤 颈椎 椎管 

分 类 号：R739.4[医药卫生—肿瘤]