着丝粒蛋白F与恶性肿瘤的关系  

Research progress of kinetochore protein CENP-F in malignant tumor

作　　者：郑瑾[1] 林英城[1] 

机构地区：[1]汕头大学医学院附属肿瘤医院内科,515031

出　　处：《国际肿瘤学杂志》2014年第7期500-502,共3页Journal of International Oncology

摘　　要：着丝粒蛋白F（CENP-F）是细胞周期依赖性的着丝粒蛋白，其表达和定位具有严格的细胞周期性。CENP-F在肿瘤发生中起重要作用。CENP-F在多种肿瘤中表达上调，是重要的细胞增殖标志物，研究显示与肿瘤的发生、发展、侵袭、复发与预后等相关，是一个有价值的肿瘤预后指标和潜在治疗靶点。CENP-Fisacell-cycledependentkinetochoreprotein,whoseexpressionandlocalization patterns are regulated in a cell cycle-dependent manner.CENP-F plays an important role in the development and progress of malignant tumor.The expression of CENP-F is up-regulated in many tumors.It serves as an important marker in cell proliferation.Studies have demonstrated that CENP-F is involved in tumor genesis, progress,invasiveness,relapse and prognosis.CENP-F might be a valuable prognostic marker and potential therapy target in cancer treatment.

关 键 词：肿瘤 预后 着丝粒蛋白F 

分 类 号：R730.2[医药卫生—肿瘤]