泥鳅冻干粉抗CCl_4小鼠肝纤维化作用  

Effect of Misgurnus anguillicaudatus Lyophilized Power on Liver Fibrosis Induced by CCl_4 in Mice

作　　者：张倩[1] 商萌萌[1] 凌去非[2] 刘春宇[1] 

机构地区：[1]苏州大学药学院,江苏苏州215123 [2]苏州大学水产研究所,江苏苏州215123

出　　处：《食品研究与开发》2014年第11期112-114,共3页Food Research and Development

基　　金：江苏省水产三项工程(PJ2011-62);连云港市赣榆县泥鳅协会项目(P113400310)

摘　　要：采用CCl4小鼠肝纤维化模型,给予不同剂量泥鳅冻干粉,检测小鼠血清中ALT、AST活性及肝组织中羟脯氨酸(Hyp)含量,并观察肝组织病理变化,探讨泥鳅冻干粉抗CCl4小鼠肝纤维化作用。结果表明,与模型组相比,泥鳅粉冻干粉明显降低CCl4诱导的肝纤维化小鼠血清ALT、AST活性,显著降低肝组织Hyp含量(P<0.05)。病理学观察结果,泥鳅粉冻干粉给药组小鼠胶原纤维沉积明显减轻,假小叶结构明显减少。泥鳅冻干粉能预防小鼠肝纤维化的形成,具有抗肝纤维化作用。To study the effect of Misgurnus anguillicaudatus lyophilized power on liver fibrosis, the model in mice was established by using CCl4. Given different doses of Misgurnus anguillicaudatus lyophilized power, the serum ALT and AST activities and tissue Hyp content were detected. The pathological changes of liver were observed. Results showed that the AST and ALT activities and Hyp levels were significantly decreased （P〈0.05） in three doses groups of Misgurnus Anguillicaudatus lyophilized power, compared with the model group. The pathological improvements were observed. The fibrogenesis in liver tissues were markedly reduced and the formation of liver pseudoluboli was alleviated. The Misgurnus anguillicaudatus lyophilized power can prevent the formation of liver fibrosis induced by CCl4 in mice.

关 键 词：泥鳅冻干粉 肝纤维化 CCL4 

分 类 号：R575.2[医药卫生—消化系统]