衡阳地区女性感染21种型别人乳头瘤病毒现状分析  

Analysis on infection status quo of 21 kinds of genotypes of human papillomavirus among women in Hengyang region

作　　者：曹清香[1] 高红[2] 唐清[1] 戴文[1] 谢文柳 万艳平[2] 

机构地区：[1]湖南省衡阳市妇幼保健院检验科,湖南衡阳421001 [2]南华大学护理学院护理学研究所,湖南衡阳421001

出　　处：《国际检验医学杂志》2014年第14期1830-1832,共3页International Journal of Laboratory Medicine

基　　金：湖南省教育厅重点项目(11A102);衡阳市科技局项目(2012KJ71)

摘　　要：目的了解衡阳地区21种型别人乳头瘤病毒(HPV)感染女性的现状与分布规律。方法以2012年4月至2013年5月在衡阳市妇幼保健院就诊自愿接受宫颈癌筛查的8 032例女性为研究对象,收集宫颈组织脱落细胞标本;采用凯普医用核酸分子快速杂交系统检测标本中21种型别HPV基因,统计分析女性HPV感染率及HPV基因分布。结果在8 032例标本中,有1 664例检出1种或2种以上的HPV,女性HPV感染率为20.72%;居前六位的HPV型别分别为HPV16、52、58、81、53、18。在1 664例HPV感染女性中,单一HPV感染率为76.44%,多重感染率为23.56%,且多为二重感染;感染HPV的各年龄组总阳性率随年龄增长呈"U"型分布,但不同年龄组总阳性率差异无统计学意义(P>0.05)。结论衡阳地区女性HPV感染率相对较高,且以高危型HPV感染为主,HPV16居第1位。Objective To investigate the infection status quo of 21 kinds of genotypes of human papillomavirus （HPV）and their distribution rule among the women in Hengyang region.Methods A total of 8 032 women voluntarily accepting cervical cancer screening in the Hengyang Municipal Maternal and Child Health Care Hospital fromg April 2012 to May 2013 were selected as the research subjects.The exfoliated cells samples of cervical tissue were collected for detecting 21 kinds of HPV genotypes by Hybri-Max.The HPV infectious rate and the HPV gene distribution were analyzed by using SSPS13.0.Results Of 8 032 women,1 664 cases were detected out 1 kind or more than 2 kinds of HPV,the HPV infectious rate was 20.72%（1 664/8 032）.The top 6 geno-types of HPV were HPV16,52,58,81,53 and 18.Among 1 664 female cases of HPV infection,the single HPV infection rate was 76.44%,the multiple infection rate was 23.56%,which was dominated by the double infection;the total positive rate in the various age groups of HPV infection presented the＆quot;U＆quot;-type distribution with the age increase,however the total positive rate had no statis-tically significant differences among all age groups（P 〉0.05 ）.Conclusion The HPV female infection rate in Hengyang region is relatively higher,moreover the high risk HPV is predominant.HPV 16 occupies the top ranking.

关 键 词：人乳头瘤病毒 基因型 感染 女性 

分 类 号：R737.33[医药卫生—肿瘤]