缺失型α-地中海贫血基因携带者红细胞参数特征研究  被引量:5

Study on characteristics of erythrocyte parameters in carriers of alpha-thalassemia deletional genotypes

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作  者:潘翠琦 白杨 刘冬冬[2] 唐芳 黄景春[2] 尚陈宇 徐建华[2] 

机构地区:[1]广州市东升医院,广东广州510120 [2]广东省中医院检验科,广东广州510120 [3]广州市人口和计划生育科学研究所,广东广州510410

出  处:《国际检验医学杂志》2014年第14期1836-1838,共3页International Journal of Laboratory Medicine

基  金:广东省人口和计划生育委员会科研项目(20132011)

摘  要:目的探讨缺失型α-地中海贫血基因携带者红细胞参数变化特点。方法经gap-PCR技术确定的389例缺失型α-地中海贫血基因携带者分为3组:(1)静止型:-α/αα型;(2)标准型:--SEA/αα型;(3)中间型或HbH型:-α/--SEA型。选取同期188名健康体检者(男性97名、女性91名)做为对照组(NC组)。采用方差分析及多重比较研究各组红细胞参数,包括RBC、Hb、MCV、MCH和RDW等变化特点。结果缺失型α-地贫表现为不同程度的小红细胞低色素症;各基因型和表现型红细胞参数间差异均有统计学意义(P<0.05),且Hb、MCV、MCH值低于对照组,并随着ɑ珠蛋白基因缺陷数目的增加,有减小的趋势;而RDW值高于对照组,有增大的趋势,差异有统计学意义(P<0.05)。389例缺失型α-地贫基因携带者中,其中静止型占19.55%,标准型占68.12%,中间型占12.33%。结论随着ɑ珠蛋白基因缺陷数目增加,小细胞低色素特征越来越显著;RBC总体增高,Hb、MCV和MCH呈下降趋势,红细胞体积大小异质性增加。MCV、MCH降低时应高度疑似地贫,但MCV、MCH正常时不能除外静止型、标准型地贫。Objective To study the change characteristics of erythrocyte parameters in carriers of deletional alpha-thalassemia gene.Methods 389 patients with deletional alpha-thalassemia gene determined by the gap-PCR technique were classified into three groups based on different genotypes of alpha-thalassemia including silent thalassemia group,alpha-thalassemia trait group (265 ca-ses)and intermediate thalassemia group,and contemporaneous 188 healthy adults were randomly selected as the normal control-group(NC).The erythrocyte parameters including RBC,Hb,MCV,MCH,RDW were retrospectively analyzed and their differences were compared among aboved-mentioned groups by the analysis of variance and the multiple comparison.Results Alpha-thalasse-mia manifested by different degrees of microcyte hypochromia.There were statistically significant differences in the erythrocyte pa-rameters among various genotypes and phenotypes about erythrocyte indices(P 〈0.05).Moreover,the Hb,MCV and MCH values were lower than those in the control group,and had the decreasing tendency with the increase of deletedα-globin gene numbers;but the RDW value was higher than that in the control group,showing the increasing tendency,the differences had statistical siginifi-cance(P 〈0.05).Conclusion With the increase of deleted α-globin gene number,the characteristic of small-cell low-hemoglobin is more and more remarkable.RBC has a overall increase,while Hb,MCV and MCH have a decreasing tendency,and the heterogeneity of erythrocyte volume is increased.When MCV and MCH decreasing in high risk region,thalassemia should be highly suspected, but normal MCV and MCH can not exclude silent thalassemia and alpha-thalassemia trait.

关 键 词:Α-地中海贫血 基因型 红细胞参数 

分 类 号:R556[医药卫生—血液循环系统疾病]

 

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