四联疗法联用枯草杆菌二联活菌肠溶胶囊治疗幽门螺杆菌的疗效观察  

Effect observation of quadruple therapy combined Medilac-S to eradicate helicobacter-pylori

作　　者：何庆玲[1] 何俊[1] 陈忠华[1] 刘雪梅[1] 

机构地区：[1]四川省宜宾市第二人民医院消化科,644000

出　　处：《临床合理用药杂志》2014年第20期8-9,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察四联疗法联用微生态制剂枯草杆菌二联活菌肠溶胶囊根除幽门螺杆菌(Hp)治疗中Hp根除率及不良反应的影响。方法将300例Hp阳性的十二指肠溃疡及慢性胃炎伴糜烂患者随机分为观察组与对照组各150例。对照组予常规四联疗法治疗,观察组在对照组基础上加用枯草杆菌二联活菌肠溶胶囊。服药第3、10天分别调查患者的不良反应发生率;治疗结束4周后复查14C-尿素呼气试验,了解Hp根除率。结果对照组与观察组Hp根除率分别为92.0%和93.3%,2组比较差异无统计学意义(P>0.05)。观察组胃肠道不良反应发生率明显低于对照组,差异有统计学意义(P<0.01)。结论传统四联疗法联用微生态制剂枯草杆菌二联活菌肠溶胶囊治疗Hp疗效显著,不良反应发生率较单用四联疗法显著降低,效果肯定,值得临床推广应用。Objective To observe the eradication rate and side-effect about quadruple therapy combined medilac-S to eradicate helicobacter-pylori. Methods 300 cases of patients with peptic ulcer or chronic gastritis were divided into observa-tion group and control group randomly,each of 150 cases. The control group was only treated by routine quadruple therapy, while the observation group was treated by quadruple therapy and medilac-S. The side-effects questionnaire was investigated on the third and tenth day. After 4 weeks,the Hp eradicate rate were compared by doing the 14 C urea breath test. Results The Hp eradication rate of the observation group and the control group were 92% and 93. 3% respectively,the difference was not statistically significant（P ﹥ 0. 05）. The gastrointestinal side-effects were obviously fewer in observation group than that in con-trol group ,the difference was statistically significant（P ﹤ 0. 01）. Conclution The effect of medilac-S combined with quad-ruple therapy is remarkable in the treatment of helicobacter - pylori ,with fewer side-effects,which is worthy of clinical applica-tion.

关 键 词：益生菌 幽门螺杆菌 四联疗法 美常安 药物不良反应 

分 类 号：R573[医药卫生—消化系统]