永存原始玻璃体增生症患儿眼轴长度及眶容积分析  

Axial length and orbital volume analysis of PHPV eyes in Children

作　　者：胡毅倩[1] 董洋[1] 王诗园[1] 冯华章[1] 周秀莉[1] 余文晶[1] 

机构地区：[1]上海交通大学医学院附属新华医院眼科, 200092

出　　处：《中国实用眼科杂志》2014年第7期895-899,共5页Chinese Journal of Practical Ophthalmology

摘　　要：目的 初步探讨永存原始玻璃体增生症（persistent hyperplastic primary vitreous,PHPV）患儿眼眶发育状况及其与眼轴发育、病变类型间关系.方法 对2009年3月至2011年8月在上海交通大学医学院附属新华医院就诊的18例PHPV患儿进行眼部超声检查、眼轴长度测量及CT三维重建眶容积分析.结果 患儿平均年龄10个月（最小56 d,最大24个月）,均单眼发病.患眼轴长（17.8±3.2） mm,眶容积（12.5±2.9） cm3;健眼轴长（20.4±2.7） mm,眶容积（13.5±3.1） cm3.患眼轴长及眶容积均显著＜对侧眼,差异有统计学意义（t值=-5.517、-5.701,P值=3.772x 104、2.598x10-5）.根据超声特征,按病变累及玻璃体前部、后部或全程,分成A组（4例）、B组（5例）、C组（9例）,计三组.A组患眼与对侧眼间眼轴长度及眶容积差异均无统计学意义（t值=-1.151、-2.485,P值=0.333、0.089）;B组患眼轴长及眶容积均＜对侧眼（t值=-2.835、-2.809,P值=0.047、0.048）.C组患眼轴长及眶容积均显著＜对侧眼（t值=-8.472、-5.365,P值=2.885x10-5、0.001）.C组双眼轴长差值显著＞A、B两组（P值=0.001、0.008）,C组双眼眶容积差均值最大,但与其他组比较差异无统计学意义（P＞0.05）.眶容积与眼轴长度呈较强差异有统计学意义（r=0.486,P=0.003）.双眼眶容积差值与眼轴长度差值差异有统计学意义（r=0.560,P=0.016）.结论 PHPV患眼眼轴发育及眶容积发育均受阻,两者存在正相关关系.单纯前部玻璃体增殖影响不明显,前后混合型影响显著.CT三维重建是有效的眶容积测量方法.Objective To study the orbital volume development and its relationship with the axial length and pathological type in children PHPV eyes.Methods Eighteen cases of children who were diagnosed PHPV in Xinhua Hospital affiliated to Medical School of Shanghai Jiaotong University from March 2009 to August 2011 performed ultrasonography of the eye and reconstructed computed tomography of the orbital.The axial length was measured and the orbital volume was calculated by computer procedure.Results The average age of these cases was 10 months （56 days to 24 months）,all were unilateral.The axial length and the orbital volume were （17.8±3.2）mm and （12.5±2.9）cm3 in PHPV eyes; while those of the lateral eyes were （20.4±2.7）mm and （13.5±3.1）cm3.Both the axial length and the orbital volume of PHPV eyes were significantly shorter and smaller compared with those of the lateral eyes （t-5.517,-5.701,P 3.772x 105,2.598x 105）.According to the anterior,posterior,and combination type of pathological characteristics shown on B-scan images,three groups were made as Group A （4 cases）,Group B （5 cases）,and Group C （9 cases）.There was no significant difference of axial length or orbital volume found between PHPV eyes and the lateral eyes in group A （t-1.151,-2.485,P 0.333,0.089）.Both the axial length and the orbital volume were statistically shorter or smaller in PHPV eyes compared with those of the lateral eyes in group B （t-2.835 and-2.809,P 0.047,0.048）.Both the axial length and the orbital volume were significantly shorter or smaller in PHPV eyes compared with those of the lateral eyes in group C （t-8.472 and-5.365,P-2.885x105,0.001）.The axial length difference between both eyes of group C was significantly larger than that of group A and group B （P 0.001,0.008）,but the orbital volume difference between both eyes showed no statistical difference among groups,although the average value was the biggest in group C （P 〉0.05）.The orbital volume was positively correlate with the ax

关 键 词：眼轴长度 眶容积 超声 CT三维重建 

分 类 号：R776.4[医药卫生—眼科]