恶性肿瘤GP方案化疗中外周血网织血小板变化的临床研究  

Clinical research on the change of reticulated platelet in cancer patients receiving GP

作　　者：萧剑军[1] 何洁冰 彭杰文[1] 殷兆锋[1] 江小梅[1] 

机构地区：[1]广东省中山市人民医院化疗科,广东中山528400 [2]广东省中山市肿瘤研究所,广东中山528400

出　　处：《中国医药科学》2014年第13期186-187,198,共3页China Medicine And Pharmacy

基　　金：2011年中山市卫生局科研立项课题;项目编号:2011A050132

摘　　要：目的：探讨外周血网织血小板在接受吉西他滨联合方案化疗的恶性肿瘤中对骨髓恢复的预测作用。方法2009年1月-2013年12月中山市人民医院接受吉西他滨联合方案化疗的恶性肿瘤患者38例，检测化疗前、化疗后每3天的血小板计数及网织血小板计数。结果38例患者中，相对于骨髓抑制期，骨髓恢复期的网织血小板升高，差异有统计学意义[（8.40±3.95）×10^9/L vs （5.77±3.58）×10^9/L，t=3.04，P=0.003]，而血小板差异无统计学意义[（51.34±11.20）×10^9/L vs （46.71±10.58）×10^9/L，t=1.85，P=0.068]。结论在接受吉西他滨联合顺铂化疗的实体瘤中，外周血网织血小板比血小板能更有效预测骨髓巨核细胞系的恢复变化。Objective To explore the predictive role of reticulated platelet on bone marrow recovery in cancer patients receiving gemcitabine-based regimen.MethodsFrom January 2009 to December 2013, a total of 38 cancer patients receiving gemcitabine-based chemotherapy were collected at zhongshan city people＇s hospital. reticulated platelet and platelet count from pre-chemotherapy to every 3 days post-chemotherapy were tested.Results For a total of 36 patients, compared to chemotherapy-induced thrombocytopenia （CIT） without imminent recovery, CIT with imminent recovery had statistically significant higher reticulated platelet count[（8.40±3.95）×10^9/L vs （5.77±3.58）×10^9/L,t=3.04,P= 0.003] and was not statistically significant higher platelet count[（51.34±11.20） ×10^9/L vs （46.71±10.58） ×10^9/L,t=1.85,P=0.068].ConclusionFor cancer patients receiving gemcitabine combined with cisplatin, peripheral blood reticulated platelets may be more effective than platelet in predicting bone marrow megakaryocytes recovery.

关 键 词：吉西他滨 网织血小板 恶性肿瘤 化疗 

分 类 号：R730.53[医药卫生—肿瘤]