现代医学对恶性肿瘤转移相关机制的研究进展  

Research progress on mechanisms of modern medicine in cancer metastasis

作　　者：陈惠[1] 渠景连[1] 龚婕宁[1] 

机构地区：[1]南京中医药大学基础医学院,江苏南京210046

出　　处：《中国中药杂志》2014年第15期2823-2828,共6页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81373603)

摘　　要：恶性肿瘤转移是恶性肿瘤发生和演变过程中最危险的阶段,是恶性肿瘤患者死亡的首要原因,临床上,60%以上的恶性肿瘤患者在发现时已经转移。近年来,现代医学对恶性肿瘤转移的机制研究取得突破性进展,从单纯的"解剖和机械"学说向"种子与土壤"学说迈进,再向微环境学说、肿瘤干细胞学说深入,特别是新兴的肿瘤干细胞学说成功解释了恶性肿瘤转移表现的肿瘤遗传异质性、失巢凋亡抗性、肿瘤休眠等现象,为恶性肿瘤转移的治疗提供了更多新的靶点与诊疗思路。Cancer metastasis is the most dangerous stage of tumorigenesis and evolution,the primary cause of death in cancer patients.Clinically,more than 60% of cancer patients have found metastasis at the time of examination.Modern medicine has made significant progress on the mechanisms of cancer metastasis in recent years,from the simple ″anatomy and machinery″ theory forward to the ″seed and soil″ theory,then to the ″microenvironmental″ theory and the ″cancer stem cell″ theory.The emerging ″cancer stem cell″theory successfully explains phenomenon such as tumor genetic heterogeneity,anoikis resistance,tumor dormancy,providing more new targets and ideas for the diagnosis and treatment of cancer metastasis.

关 键 词：现代医学 恶性肿瘤 转移机制 上皮间质转化 肿瘤干细胞 

分 类 号：R73-37[医药卫生—肿瘤]