原发性肝癌患者肝动脉栓塞化疗后医院感染的危险因素研究  

Risk factors for nosocomial infections after hepatic arterial chemoembolization for patients with primary liver cancer

作　　者：董礼阳[1] 周为中[1] 胡文豪[1] 余昶[1] 黄士勇[1] 倪俊伟 

机构地区：[1]温州医科大学附属第一医院介入科,浙江温州325000

出　　处：《中华医院感染学杂志》2014年第15期3770-3772,共3页Chinese Journal of Nosocomiology

基　　金：浙江省卫生厅重点基金资助项目(ZW-2010B-1018)

摘　　要：目的探讨原发性肝癌行肝动脉栓塞化疗患者发生医院感染的危险因素,以采取相应措施,降低医院感染的发生率。方法选取2011年4月-2013年5月原发性肝癌患者511例,对其发生医院感染基本资料和临床治疗情况进行回顾性分析,采用SPSS13.0软件进行统计分析。结果 511例患者共发生医院感染136例,感染率为26.61%;经过logistic回归分析,血清白蛋白水平≤30g/L、白细胞计数<1.0×109/L、住院时间>42d、皮肤或者黏膜有溃疡、侵入性操作、广谱抗菌药物应用>20d、合并糖尿病为发生医院感染的独立危险因素(P<0.05)。结论原发性肝癌肝动脉栓塞化疗患者发生医院感染的危险因素多样,在临床工作中应给予针对性的干预措施,减少医院感染发生率。OBJECTIVE To investigate risk factors for nosocomial infections after hepatic arterial chemoembolization for patients with primary liver cancer so as to take appropriate measures to reduce the incidence of nosocomial infections. METHODS Totally 511 patients with primary liver cancer admitted during Apr. 2011 to May 2013 were selected; their basic information and clinical treatment were analyzed retrospectively with SPSS 13.0. RESULTS There were a total of 136 cases of nosocomial infections in the 511 patients, the infection rate was 26.61%. The logistic regression analysis showed albumin levels ≤ 30 g/L, white blood cell count 〈1.0 ×10^9/L, length of stay 〉42 days, skin or mucous membrane ulcers, invasive procedures, use of broad-spectrum antibiotics 〉20 days, and occurrence of diabetes were the independent risk factors for nosocomial infections （P〈0.05）. CONCLUSION There are various risk factors for nosocomial infection after hepatic arterial chemoembolization for patients with primary liver cancer. In clinical work, clinicians should given target interventions to reduce the incidence of nosocomial infection.

关 键 词：原发肝癌 肝动脉栓塞 化疗 医院感染 危险因素 

分 类 号：R735.7[医药卫生—肿瘤]