老年脑梗死患者血清中性粒细胞明胶酶脂质运载蛋白及凝集素样氧化型低密度脂蛋白受体-1水平的表达及临床意义  

Discussion and clinical significance of the neutrophil gelatinase associated lipoclin and lectin-like oxidized low-density lipoprotein receptor-1 expression in the elderly cervical atherosclerosis cerebral infarction patients

作　　者：杨剑文 杨期明 雷涛 卢伟[2] 雷翔[2] 刘雄鹤 

机构地区：[1]湖南省老年医院神经内科,长沙410015 [2]中南大学湘雅二院神经内科 [3]湖南省老年医院影像科

出　　处：《中华脑科疾病与康复杂志（电子版）》2014年第4期33-36,共4页Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）

基　　金：湖南省科技厅资助项目(2011FJ3138)

摘　　要：目的分析老年颈内动脉粥样硬化脑梗死患者血清中性粒细胞明胶酶脂质运载蛋白(NGAL)、凝集素样氧化型低密度脂蛋白受体-1(sLox-1)表达及颈动脉内膜改变,探讨其临床意义。方法收集2012年3月至2013年9月在湖南省老年医院神经内科确诊为动脉粥样硬化脑梗死患者70例为A组,颈内动脉粥样硬化患者72例为B组,两组按随机分组法再分为常规治疗组和强化治疗组两个亚组,分别在0周、12周、24周时采用酶联免疫吸附法测定患者血清NGAL、sLox-1水平,并同时测定患者的颈动脉内膜中层厚度和斑块面积,数据结果采用SPSS 17.0软件进行统计分析。结果脑梗死组患者血清中NGAL和sLox-1的表达水平、颈动脉内膜中层厚度及斑块面积均高于动脉硬化组(P<0.05),阿托伐他汀治疗24周后强化亚组下降明显(P<0.05),且颈动脉内膜中层厚度及斑块面积较前降低(P<0.05)。结论血清NGAL及sLox-1参与动脉粥样硬化性脑梗死的发生机制,强化调脂治疗后其表达水平下调。Objective To analyze the neutrophil gelatinase associated lipoclin （ NGAL） and lectin-like oxidized low-density lipoprotein receptor-1 （ sLox-1 ） of the elderly cervical atherosclerosis cerebral infarction patients,and to discuss the clinical significance of the NGAL and sLox-1.Methods Totally 142 cases from March 2012 to September 2013 in the Neurology Department of Geriatric Hospital of Hunan Province were collected in this study , they were divided into two groups , group A （ 70 cases diagnosed of atherosclerosis cerebral infarction ） , group B （ 72 cases with carotid atherosclerosis ） .They were randomly divided into conventional therapy subgroup and intensification therapy subgroup respectively ,on the 0 week, 12 weeks,24 weeks,measure the serum of NGAL and sLox-1 levels,the intimae media thickness（IMT）and the plaque area in patients with ELISA .And the IMT of carotid artery and plaque area were measured , the data were analyzed by SPSS 17.0.Results In cerebral infarction group ,the serum levels of NGAL and sLox-1, the carotid IMT and plaque area were higher than those in the atherosclerosis group （P〈0.05）,the intensive subgroup decreased significantly by atorvastatin treatment after 24 weeks （ P〈0.05 ） , and carotid IMT and plaque area were reduced compared with the previous （ P 〈0.05 ） .Conclusion The NGAL and sLox-1 participate in the pathogenesis of atherosclerotic cerebral infarction , and the expression are declined with intensive lipid-lowering .

关 键 词：脑梗死 中性粒细胞明胶酶脂质运载蛋白 颈动脉内膜 

分 类 号：R743.3[医药卫生—神经病学与精神病学]