血管细胞粘附分子1在肿瘤神经侵袭中的作用研究  

Vascular Cell Adhesion Molecule 1 in the Role of Nerve Tumor Research

作　　者：夏启俊[1] 李涛[1] 陈凛[1] 

机构地区：[1]中国人民解放军总医院,100853

出　　处：《首都医药》2014年第14期20-22,共3页Capital Medicine

基　　金：国家自然科学基金(编号:81272698;81101883;81172368);国家青年科学基金(编号:31200798)

摘　　要：目的综述血管细胞粘附分子1在肿瘤神经侵袭中的作用。方法本文就血管细胞粘附分子1在肿瘤神经侵袭中的作用作一综述。结果与结论神经侵袭是多种恶性肿瘤的转移途径之一,常导致局部复发及疼痛,影响疾病预后,但目前神经侵袭的机制尚缺乏定论。血管细胞粘附分子1属免疫球蛋白超家族结构的粘附分子,参入多种恶性肿瘤的发生发展及转移,同时参入神经的发生。Objective Review vascular cell adhesion molecule 1 role in nerve tumor. Methods We present a brief review of literature on the topic of the role of VCAM1 in PNI of cancers.Result and ConclusionPerineural invasion （PNI） is one of the important routes for metastasis of cancers associated with poor prognosis and frequently results in local recurrence and cancer pain.However,the underlying mechanism of PNI has been unclear and need to further study.Vascular cell adhesion molecule 1（VCAM1）,one of the immunoglobulin superfamily adhesion molecules,involved in the occurrence and metastasis of cancers as well as neurogenesis.

关 键 词：肿瘤 神经侵袭 血管细胞粘附分子 

分 类 号：R730.3[医药卫生—肿瘤]