乒乓球运动结合叶酸、Vit B_(12)干预对阿尔茨海默病患者功能改善的研究  

Intervention of Effects of Table Tennis Playing Combined with Folic Acid,Vit B_(12) on Patients with Alzheimer's Disease

作　　者：胡启凯[1] 王春芳[2] 

机构地区：[1]山西中医学院体育部,山西太原030024 [2]山西医科大学医学实验中心,山西太原030001

出　　处：《武汉体育学院学报》2014年第8期86-90,共5页Journal of Wuhan Sports University

基　　金：国家自然科学基金(30672114);山西省自然科学基金(20090110571)

摘　　要：目的:观察乒乓球运动结合补充叶酸、Vit B12对AD(阿尔茨海默病)患者功能改善的影响。方法:选取2011年10月-2012年10月太原市符合CCMD-HE和NINCDS标准,并能积极配合观察的AD患者120例,随机分为实验组(60例)和对照组(60例);对照组每日服用叶酸10mg,Vit B12 500μg;实验组患者在对照组治疗基础上每隔一日进行1小时的乒乓球运动。运动干预时间为1年;在实验前后对对照组和实验组患者进MMSE(简易智力状态量表)和ADL(日常生活活动能力量表)测定;采用荧光高效液相色谱法(HPLC)进行尿液甲醛检测,采用酶联免疫吸附测定(ELISA)法检测患者尿中AD7cNTP(神经丝蛋白)的含量。结果:与对照组65%的总有效率相比,实验组总有效率达到85%,乒乓球运动干预后实验组整体疗效明显优于对照组;对照组MMSE实验前后评分均值分别为(21.24±4.12)、(24.67±4.06),ADL为(24.86±4.35)、(20.56±4.65);实验组MMSE干预前后均值分别为(21.46±4.08)、(26.77±3.84),ADL为(25.34±4.56)、(20.06±5.24);MMSE评分实验组与对照组有显著性差异,ADL分值无明显差异;对照组尿中甲醛含量实验前后分别为(1.35±0.14)mmol/L、(0.45±0.07)mmol/L,尿中AD7c-NTP含量为(5.54±0.46)ng/mL、(2.75±0.62)ng/mL;实验组尿中甲醛含量前后分别为(1.32±0.34)mmol/L、(0.17±0.09)mmol/L,尿中AD7c-NTP含量为(5.02±0.56)ng/mL、(1.46±0.28)ng/mL;尿中甲醛和AD7c-NTP含量差异均有统计学意义。结论:乒乓球运动结合补充叶酸、Vit B12对AD患者功能改善具有明显作用;乒乓球运动可以作为AD患者的协助治疗。The purpose of this study was to observe the effects of table tennis playing combined with folic acid,B12 on pa-tients with alzheimer＇s disease （AD）.120 patients accordant with CCMD-HE and NINCDS standard were selected and randomly divided into experimental group and control group.Patients in the control group took a daily dose of 10mg folic acid and Vit B12 500 ug.Patients in the experimental group took the dose and took an hour table tennis exercise every one day for one year.Then the Mini Mental State Scale （MMSE）and activities of daily living scale （ADL）were measured. Meanwhile,the level of formaldehyde and neurofilament protein （AD7c-TP）in the urine was also detected by HPLC and control group,that of the experimental group was 85%. The curative effect for the experimental group was better than that of the control group （P 〈 0.05 ）.The MMSE score mean before and after the experiment for the control group was （21.24 ±4.12）and （24.67 ±4.06）.ADL was （25.34 ±4.56）and （20.06 ±5.24）.There was signifi cant difference of MMSE （P 〈0.05）but not of ADL.For the control group,the level of formaldehyde before and after the experiment was （1.35 ±0.14）mmol/L,（0.45 ±0.07）mmol/L,AD7c-NTP （5.02 ±0.56）ng/mL,and （2.75± 0.62）ng/mL.There was significant difference of formaldehyde and AD7c-NTP content in urine （P 〈0.05）.It could be concluded that the function of AD patients were significantly improved by the treatment with folic acid,Vit B12 combined with table tennis playing.

关 键 词：AD患者 叶酸 VIT B12 尿甲醛 AD7c-NTP 乒乓球运动 

分 类 号：G804.5[文化科学—运动人体科学]