尿液中尿膀胱癌抗原和钙网蛋白联合检测对原发性膀胱癌的诊断价值  

Value of Combined Detection of Urinary Bladder Cancer Antigen and Calreticulin from Urine in the Diagnosis of Bladder Cancer

作　　者：史沁兵[1] 唐晓磊[2] 

机构地区：[1]郑煤集团总医院泌尿外科,河南郑州452371 [2]皖南医学院弋矶山医院检验科,安徽芜湖241001

出　　处：《肿瘤基础与临床》2014年第4期341-342,共2页journal of basic and clinical oncology

摘　　要：目的评价尿液中尿膀胱癌抗原(UBC)和钙网蛋白(CRT)联合检测对原发性膀胱癌的诊断价值。方法 76例膀胱癌患者、50例泌尿系统良性疾病患者均在膀胱镜检查前留取尿液,用ELISA法进行UBC、CRT定量检测,同时进行尿液中脱落细胞学检测。结果 UBC和CRT诊断膀胱癌的敏感性分别为89.47%和82.89%,高于脱落细胞学的51.32%(P<0.05);3种诊断方法对膀胱癌的诊断特异性分别为92.00%、78.00%和94.00%。联合检测UBC和CRT诊断膀胱癌的敏感性和特异性高达94.74%、94.00%。结论尿液中UBC和CRT是早期诊断膀胱癌较好的肿瘤标志物,而两者联合检测能进一步提高诊断效率。Objective To assess the value of combined detection of urinary bladder cancer antigen（ UBC） and calreticulin（ CRT） from urine in the diagnosis of bladder cancer. Methods The 76 patients with bladder cancer and 50 patients with urinary benign disease were collected. The UBC and CRT from urine were detected by ELISA method. In additional,the exfoliative cytology were observed by microscope. Results The sensitivities of UBC（ 89.47%） and CRT（ 82.89%） were significantly higher than that of urine cytology（ 51.32%）（ P〈 0.05）. The specificities of UBC,CRT and urine cytology were 92. 00%,78. 00% and 94. 00%,respectively. The sensitivity and specificity of combined detection of UBC and CRT were 94. 74% and 94. 00%. Conclusion UBC and CRT are better diagnostic tumor markers for the early diagnosis of bladder cancer,the combined detection can improve the diagnostic efficacy.

关 键 词：膀胱癌 尿膀胱癌抗原 钙网蛋白 

分 类 号：R737.14[医药卫生—肿瘤] R730.43[医药卫生—临床医学]