157例卵巢肿瘤中IFT20的表达及意义  

Expression of IFT20 in 157 cases of ovarian serous tumor and its clinical significance

作　　者：牛娜[1] 刘乾[1] 程丽[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院妇科,哈尔滨150040

出　　处：《临床与实验病理学杂志》2014年第7期736-740,共5页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的观察纤毛内转运蛋白20(intraflagellar transport 20,IFT20)在卵巢良、恶性肿瘤中的表达,探讨其与卵巢癌发生、发展及预后的关系。方法采用免疫组化SP法检测IFT20在157例卵巢肿瘤组织中的表达,其中浆液性囊腺癌52例、黏液性囊腺癌22例、子宫内膜样腺癌14例、透明细胞腺癌10例、交界性卵巢肿瘤25例、良性肿瘤18例及正常卵巢组织16例。结果(1)IFT20在卵巢癌组织(76.5%,75/98)和交界性肿瘤组织(32%,8/25)中的阳性率明显高于卵巢良性肿瘤(16.6%,3/18)和正常卵巢组织(12.5%,2/16),组间差异有统计学意义(P<0.05);(2)IFT20蛋白在不同FIGO分期和组织学分级的卵巢癌组织中的表达差异有显著性(P<0.05),随着FIGO分期和组织学分级的升高,且伴有淋巴结转移的卵巢癌组织中IFT20蛋白的表达显著升高;(3)IFT20蛋白表达强弱与患者生存时间呈负相关(P<0.05)。(4)IFT20蛋白表达与卵巢癌患者年龄无关。结论 IFT20蛋白与卵巢癌的发生、浸润和转移相关,在一定程度上可判断卵巢癌恶性程度和评估临床预后,同时为卵巢癌的靶向治疗提供新靶点。Purpose To explore the expression and clinical significance of IFT20 gene in epithelial ovarian tumor. Methods Expression of IFT20 gene was evaluated by immunohistochemistry method in 157 cases, including 52 serous cystadeno carcinoma, 22 mucin- ous cystadeno carcinoma, 14 endometriold carcimoma, 10 clear cell carcinoma. And the expression of IFT20 gene in 25 borderline ovarian tumor, 18 benign ovarian tumors, and 16 normal ovarian tissues. Results 1 ） IFT20 protein was highly expressed in ovarian cancer tissue. Positive expression rate of IFT20 in tumor tissues （ 76. 5% , 75/98 and borderline tissue （ 32% , 8/25 ） was significantly stronger than in benign ovarian tumors （16. 6%, 3/18 ） and normal ovarian tissues （12. 5%, 2/16 ）, was significantly different （P 〈 0. 05）. （2） Expression of IFT20 gene were inflected by the clinical stage, histological grade, lymph node metastasis （P 〈 0.05 ）. （3） In a multivariate Cox regression model, positive expression of IFT20 gene was negative with overall survival. （4） Expression of IFT20 gene was not iniluence by the age. Conclusion IFT20 can directly or indirectly regulate the initiation and development of ovarian cancer. IFT20 gene participate in the occurrence, invasion and metastasis of ovarian cancer, which can be used as an index to judge the malignant degree of ovarian cancer and evaluate prognosis to some extent. Therefore, IFT20 is a potential therapeutic target for cancer treatment.

关 键 词：卵巢肿瘤 IFT20 预后 免疫组织化学 

分 类 号：R737.31[医药卫生—肿瘤]