丁苯酞注射液治疗急性脑梗死临床研究  

Clinical Study on Butylphthalide Injection for Treatment of Acute Cerebral Infarction

作　　者：李鹏翔[1] 苏庆杰[1] 蔡毅[1] 曾超胜[1] 刘姝[1] 龙发青[1] 

机构地区：[1]海南省农垦总医院神经内科,海南海口570311

出　　处：《昆明医科大学学报》2014年第8期103-105,共3页Journal of Kunming Medical University

基　　金：海南省卫生厅科研基金重点项目(琼卫2010重点-40)

摘　　要：目的观察丁苯酞氯化钠注射液治疗急性脑梗死的临床疗效及安全性.方法收集2013年1月至2013年9月在海南省农垦总医院住院的39例急性脑梗死患者,随机分为2组,对照组行常规治疗,丁苯酞治疗组在常规治疗基础上加用丁苯酞氯化钠注射液治疗,0.1 g,Bid,使用21 d.2组患者分别在入院时、治疗后10 d和治疗后21 d运用美国国立卫生研究院卒中量表(NIHSS)进行神经功能评定,并在治疗后21 d运用改良RanKin量表(mRS)评估治疗效果,同时观察相关不良反应.结果 2组患者经治疗后神经功能均有恢复,但丁苯酞组患者的神经功能恢复更好(P<0.05),且丁苯酞组的治疗有效率比常规治疗组高(P<0.05).结论丁苯酞氯化钠注射液能明显改善急性脑梗死患者神经功能,治疗效果肯定,安全性较好,值得临床推广应用.Objective To evaluate the efficacy and safety of butyl-phthalide injection in the treatment of acute cerebral infarction.Methods From January 2013 to September 2013,43 patients with acute cerebral infarction in our hospital were randomly divided into two groups,the control group received routine therapy,the treatment group on the basis of conventional treatment received Butylphthalide injection treatment,0.1,bid,for 21 days.Two groups of patients were assessed with NIHSS on admission,10 d and 21 d after treatment,and the modified RanKin scale （mRS） was used to evaluate the efficacy of treatment 21 d after treatment,and at the same time we observed the related adverse reactions.Results The nerve functions of 2 groups of patients were recovered after treatment,the nerve function of butylphthalide group had better recovery than the conventional treatment group （P＜0.05）,and also the effective rate of butylphthalide group was higher （P＜0.05）.Conclusion Butyl phthalide injection could obviously improve neural function in patients with acute cerebral infarction,is has good effect and safety,so it is worthy of clinical application.

关 键 词：丁苯酞 脑梗死 临床研究 

分 类 号：R743.33[医药卫生—神经病学与精神病学]