Her2在介导乳腺癌细胞上皮间质转换中的作用研究  

Study on the Effect of Her2 Mediating Breast Cancer Cells Epithelial Mesenchymal Transition

作　　者：吕俊宏[1] 吴政光[2] 蔡长青[3] 彭盘俐[3] 

机构地区：[1]广东省第二人民医院心胸外科,广东广州510317 [2]广东省第二人民医院放射科,广东广州510317 [3]广东省第二人民医院肿瘤二科,广东广州510317

出　　处：《罕少疾病杂志》2014年第4期27-30,37,共5页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨人类表皮生长因子受体2(Her2)在介导乳腺癌细胞上皮间质转换中的作用。方法采用免疫组化方法检测156例乳腺癌组织标本中Her2、上皮样细胞标志E-钙黏素(E-cadherin)、间质样细胞标志N-钙黏素(N-cadherin)表达,根据Her2表达情况将患者分为Her2阳性组与Her2阴性组,比较两组患者E-cadherin N-cadherin表达情况。结果与Her2阴性组比较,Her2阳性组E-cadherin阳性表达率明显降低(75%VS39.47%),N-cadherin明显升高(30%VS61.84%),两组比较差异均具有统计学意义(P<0.05);E-cadherin、N-cadherin两者表达与TNM分期、淋巴结转移有关(P<0.05),表现为TNM分期和淋巴结转移程度越严重,E-cadherin阳性表达越低,N-cadherin阳性表达越高;Her2、N-cadherin阳性表达患者的病死率更高,而E-cadherin阴性表达患者的病死率更高,阴性组与阳性组比较差异具有统计学意义(P<0.05)。结论Her2阳性表达促进乳腺癌细胞上皮间质转换过程,同时增强乳腺癌的浸润转移能力,严重影响患者的预后情况。Objective To discuss the effect of human epidermal growth factor receptor 2 （Her2） mediating breast cancer cells epithelial mesenchymal transition. Methods 156 cases Her2, E-cadherin N-cadherin express in breast cancer tissues were detected by using immunohisto-chemical. According to the level of Her2 expression, patients were divided into Her2 positive group and Her2 negative group. Results Compared with Her2 negative group, E-cadherin positive expression rates of Her2 positive group decreased significantly（75%VS39.47%）, and N-cadherin positive expression rates increased significantly（30%VS61.84%） （P〈0.05）. E-cadherin, N-cadherin expression are closely related to TNM staging and the degree of lymph node metastasis （P〈0.05）. E-cadherin expression is lower and N-cadherin expression is higher with the aggravation of TNM staging and lymph node metastasis. The fatality rate of Her2, N-cadherin positive expression patients is higher, and E-cadherin negative expression patients is higher（P〈0.05）. Conclusion Her2 positive expression can promote EMT process of breast cancer cells and enhance the invasion and metastasis degree of breast cancer. The expression of Her2 could influence the prognosis of patients.

关 键 词：Her2 乳腺癌 上皮间质转换 

分 类 号：R737.9[医药卫生—肿瘤]