布拉酵母菌联合标准三联疗法治疗幽门螺杆菌消化性溃疡55例效果分析  

An analysis of the curative effect of saccharomyces boulardii combined with a standard triple therapy in the treatment of 55 cases of helicobacter pylori-induced peptic ulcer

作　　者：朱路平[1] 肖飞 

机构地区：[1]河南省疾病预防控制中心门诊部药房,河南郑州450003 [2]河南省鹤壁市人民医院儿科,河南鹤壁458030

出　　处：《中国现代医生》2014年第23期25-27,共3页China Modern Doctor

摘　　要：目的分析布拉酵母菌联合标准三联疗法治疗幽门螺杆菌消化性溃疡的临床疗效和安全性。方法随机将109例确诊幽门螺杆菌消化性溃疡进行分组,对照组54例予标准三联疗法治疗,实验组55例予布拉氏酵母菌联合标准三联疗法治疗,观察两组溃疡愈合效果、幽门螺杆菌清除率和不良反应情况。结果实验组溃疡愈合总有效率92.73%明显高于对照组79.63%(P<0.05);实验组幽门螺杆菌清除率90.91%明显高于对照组75.93%(P<0.05);实验组不良反应发生率12.73%与对照组11.11%比较,差异无统计学意义(P>0.05)。结论布拉氏酵母菌联合标准三联疗法能够通过快速恢复幽门螺杆菌消化性溃疡患者肠道菌群的动态平衡、抑制幽门螺杆菌在胃黏膜上皮定值和成长等作用提高幽门螺杆菌清除率。Objective To analyze the clinical effect and safety of saccharomyces boulardii combined with a standard triple therapy in the treatment of helicobacter pylori-induced peptic ulcer. Methods A total of 109 patients who were diagnosed as helicobacter pylori-induced peptic ulcer were randomly assigned to control group and experimental group. The control group of 54 patients received a standard triple therapy, and the experimental group of 55 patients received saccharomyces boulardii combined with a standard triple therapy. Ulcer recovery, clearance rate of helicobacter pylori and adverse events were observed between the two groups. Results The total effective rate of ulcer recovery in the experimental group was 92.73%, significantly higher than that of 79.63% in the control group（P〈0.05）; The clearance rate of helicobacter pylori in the experimental group was 90.91%, significantly higher than that of 75.93% in the control group （P〈0.05）; The incidence of adverse events in the experimental group was 12.73%, and P value was over 0.05 compared to that of 11.11% in the control group. Conclusion The saccharomyces boulardii combined with a standard triple therapy in the treatment of helicobacter pylori-induced peptic ulcer has a significantly effect, and is able to enhance the clearance rate of helicobacter pylori and the curative effect via a rapid recovery of the dynamic equilibrium of intestinal flora, and an inhibition of the gastric epithelial value and growth of helicobacter pylori.

关 键 词：布拉氏酵母菌 标准三联疗法 幽门螺杆菌 消化性溃疡 

分 类 号：R573.1[医药卫生—消化系统]