非酒精性脂肪性肝病与冠状动脉粥样硬化的关系  

Association between the non-alcoholic fatty liver disease and coronary atherosclerosis

作　　者：谢双林[1] 缪敏[2] 王勇[3] 徐磊[1] 丁小云[1] 

机构地区：[1]宁波市第一医院消化内科,浙江宁波315010 [2]宁波大学附属医院,浙江宁波315020 [3]宁波市第一医院心血管科,浙江宁波315010

出　　处：《中国现代医生》2014年第23期111-113,共3页China Modern Doctor

基　　金：浙江省自然科学基金(LY13H030012);浙江省中医药科学研究基金计划(2010ZB127);浙江省宁波市医学科技计划项目(2010B03)

摘　　要：目的探讨非酒精性脂肪性肝病与冠状动脉粥样硬化的关系。方法采用病例对照研究的方法,选取疑诊冠状动脉粥样硬化性心脏病并拟行冠状动脉造影术的患者为研究对象,其中59例诊断为非酒精脂肪性肝病(Non-alcoholic fatty liver disease,NAFLD)的患者为病例组,另外41例非NAFLD的患者为对照组。采用冠脉造影诊断冠状动脉粥样硬化性心脏病,并评估冠状动脉粥样硬化的严重度,同时检测体重、身高等一般资料以及转氨酶、血脂、血糖等生化指标。结果 NAFLD患者冠状动脉粥样硬化性心脏病的患病率高于对照组。同时,NAFLD患者的冠状动脉粥样硬化严重度评分(Gensini积分)也高于对照组。结论 NAFLD与冠状动脉粥样硬化具有密切关系。Objective To explore the association between the non-alcoholic fatty liver disease （NAFLD） and coronary atherosclerosis. Methods A case control study performed, patients suspected coronary atherosclerotic heart disease included, coronary angiography done to diagnosis the coronary atherosclerosis, and assess the severity of coronary atherosclerosis. NAFLD were diagnosed in 59 patients, 41 cases of non-NAFLD patients defined as control group. The weight, height and other body information, transaminase, cholesterol, blood sugar and other biochemical markers were assessed. Results The prevalence of NAFLD was higher in the patients with coronary atherosclerosis than the control group. Meanwhile, the coronary atherosclerosis severity score （Gensini score） were higher in NAFLD patients than the control group. Conclusion There is significant association between NAFLD and coronary atherosclerosis.

关 键 词：非酒精性脂肪性肝病 冠状动脉粥样硬化 

分 类 号：R575.5[医药卫生—消化系统]