水溶性Fe_3O_4/Au纳米复合粒子制备及性能研究  

Synthesis and Properties of Water Soluble Fe_3O_4/Au Hybrid Nanoparticles

作　　者：吴丽娜[1] 刘立洵[2] 范丽馨 王志江[2] 王可铮[1] 孙夕林[1] 申宝忠[1] 

机构地区：[1]哈尔滨医科大学附属第四医院分子影像科,黑龙江哈尔滨150001 [2]哈尔滨工业大学化工学院,黑龙江哈尔滨150001

出　　处：《节能技术》2014年第4期305-307,317,共4页Energy Conservation Technology

基　　金：黑龙江省教育厅科学技术研究项目(12511325)

摘　　要：本文针对可用作MRI/CT双模式成像分子探针的Fe3O4/Au纳米粒子制备方法存在工艺繁琐,工业扩大化后能耗大等缺点,发展了一种绿色、简便的可控自组装工艺,分析了纳米复合材料的微观结构特征,研究了材料的等离子体共振特性和磁学特征。结果表明:(1)发展的层层自组装方法可以使磁性纳米粒子Fe3O4与具有高X射线吸收的Au粒子组装在一起,两者结合牢固,长时间超声振荡后仍然没有脱落;(2)中心核为Fe3O4纳米团簇的结构特征使复合粒子具有高饱和磁化强度,克服了以往报道的Fe3O4/Au复合纳米粒子磁化强度低的缺点;(3)金粒子均匀分布在Fe3O4纳米团簇表面,因为粒子间距缩短增强了粒子间的耦合作用,使得等离子体共振谱发生了宽化和红移。To address the issue that Fe3O4/Au hybrid nanoparticles as the dual-functional MRI/CT probes are currently synthesized in a complex and energy consuming means,a facile and efficient layer-by-layer assembly technique has been developed to fabricate Fe3O4/Au hybrid nanoparticles.Their microstructure,superparamagnetic and plasmonic resonance properties were characterized and studied.Experimental Results showed：（1） Analysis on microstructure indicates that gold nanoparticles had tightly linked with magnetic Fe3O4 nanoparticle clusters which can endure long period of ultrasound vibration; （2） The structure with a core of Fe3O4 nanoparticle clusters endowed the prepared hybrid nanoparticles with a high saturation magnetization,which well overcome the shortcomings of reported Fe3O4-based hybrids with poor magnetization; （3） Gold nanoparticles attached on the surface of Fe3O4 nanoparticle clusters without aggregation.Because the distances of gold nanoparticles were reduced compared to their colloidal state,the plamonic resonance peak showed a characteristic of red-shift and broaden.

关 键 词：FE3O4 Au纳米复合粒子 层层自组装 化学键合 超顺磁 等离子体共振 

分 类 号：R445[医药卫生—影像医学与核医学]