乳果糖联合枯草杆菌二联活菌治疗便秘型肠易激综合征的临床评价  

Lactulose combined with Bacillus subtilis duplex living bacterium in treatment of patients with constipation-predominant irritable bowel syndrome

作　　者：徐进[1] 成健康[1] 杜勇[1] 胡素芳[1] 

机构地区：[1]湖北医药学院附属人民医院消化内科,湖北十堰442000

出　　处：《中国医师进修杂志》2014年第22期38-41,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨乳果糖联合枯草杆菌二联活菌治疗便秘型肠易激综合征的临床疗效。方法选择98例便秘型肠易激综合征患者，根据治疗药物分为3组：乳果糖组33例，枯草杆菌二联活菌组30例，联合治疗组35例，且三组均口服莫沙必利，疗程均为2周，观察患者腹痛、腹胀的症状、大便情况以及治疗前后生活质量改善情况。结果联合治疗组腹痛和腹胀改善总有效率明显高于乳果糖组和枯草杆菌二联活菌组，乳果糖组明显高于枯草杆菌二联活菌组，差异有统计学意义（P〈0．05）。各组问治疗前大便Bristol分级构成比较差异无统计学意义（P〉0．05）。各组间治疗后大便Bristol分级构成比较差异有统计学意义（P〈0．05）。三组大便Bristol分级构成治疗后与治疗前比较差异有统计学意义（P〈0．05）。治疗前三组问生活质量评分比较差异无统计学意义（P〉0．05），三组治疗后生活质量评分均高于治疗前，差异有统计学意义（P〈0．05）；治疗后联合治疗组生活质量评分明显高于乳果糖组，乳果糖组明显高于枯草杆菌二联活菌组，差异有统计学意义（P〈0．05）。结论乳果糖联合枯草杆菌二联活菌治疗便秘型肠易激综合征明显优于单用乳果糖及枯草杆菌二联活菌，值得临床应用。Objective To investigate the therapeutic efficacy of lactulose combined with Bacillus subtilis duplex living bacterium in patients with constipation-predominant irritable bowel syndrome. Methods A total of 98 patients with constipation-predominant irritable bowel syndrome were divided into 3 groups according to the therapeutic drugs：lactulose group （33 cases）,Bacillus subtilis duplex living bacterium group （30 cases） and combined treatment group （35 cases）,and patients in all groups received mosapride. The course of treatment was 2 weeks in all groups. The symptoms of patients with abdominal pain, abdominal distention, defecate condition and quality of life before and after treatment was observed. Results The total efficacy of abdominal pain, abdominal distention in combined treatment group was higher than that in lactulose group and Bacillus subtilis duplex living bacterium group, in lactulose group was higher than that in Bacillus subtilis duplex living bacterium group, and there was significant difference （P 〈 0.05 ）. There was no significant difference in defecate Bristol grade before treatment among three groups （P 〉 0.05 ）. There was significant difference in defecate Bristol grade after treatment among three groups （P 〈 0.05 ）. There was significant difference in defecate Bristol grade before and after treatment in three groups（P 〈 0.05）. There was no significant difference in the quality of life before treatment among three groups （P 〉 0.05 ）, the quality of life after treatment in three groups was higher than that before treatment,and there was significant difference （P 〈 0.05 ）. After treatment, the quality of life in combined treatment group was higher than that in lactulose group, in lactulose group was higher than that in Bacillus subtilis duplex living bacterium group, and there was significant difference （P 〈 0.05）. Conclusions The combined regimen of lactulose and Bacillus subtilis duplex living bacterium is more effective than lactulose or B

关 键 词：乳果糖 便秘 肠易激综合征 益生菌 

分 类 号：R574[医药卫生—消化系统]