维生素D受体位点基因多态性与自身免疫性肝病易感性的关系  

Association of vitamin D receptor gene polymorphisms with autoimmune liver diseases risk

作　　者：杨晓丹[1] 李莉华[1] 范艳玲[1] 余波[1] 郭子健[1] 

机构地区：[1]苏州大学附属第四医院肿瘤研究所,江苏无锡214062

出　　处：《中国医师进修杂志》2014年第22期41-45,共5页Chinese Journal of Postgraduates of Medicine

摘　　要：目的明确维生素D受体位点（Apal、Bsml、Taql）基因多态性与自身免疫性肝病易感性的关系。方法通过Pubmed、Ovid、Medline和Web of science databases数据库检索相关病例对照试验文献，并按照纳入、排除标准纳入本研究。对人选研究中有关试验设计、研究对象的特征、研究结果等内容进行摘录，并用STATA version 12．0软件进行分析，关联强度用比值比（OR）和95％可信区间（ci）表示。结果共收集到2000年1月至2012年2月国内外公开发表的6篇论著包括9项试验研究符合纳入标准，其中7项研究关于原发性胆汁性肝硬化（PBC），2项研究关于自身免疫性肝炎（AIH），累计病例为844例，对照为1522例。总研究人群分析显示Apal位点基因中a等位基因降低自身免疫性肝病的发病风险（等位基因模型a比A：OR值0．85，95％CI0．74～0．96，P=0．058；纯合子模型8a比AA：OR值0．75，95％C10．58～0．97，P=0．212；杂合子模型Aa比AA：OR值0．78，95％C10．63～0．98，P=0．235；显性模型Aa／aa比AA：OR值0．77，95％C10．63～0．94，P=0．231），然而Bsml和Taql位点基因并未发现与自身免疫性肝病具有相关性。结论维生素D受体Apal位点基因中a等位基因可能是自身免疫性肝病的保护基因，而Bsml和Taql位点基因与自身免疫性肝病的易感件无相关件。Objective To investigate the association of vitamin D receptor gene （Apa1, Bsm1, Taq1） polymorphisms with autoimmune liver diseases risk. Methods Case control test documents were retrieved through Pubmed,Ovid, Medline, and Web of science databases, according to the inclusion and exclusion criteria included in this study. The design of experiments, the characteristics of the object of study, research results was excerpted,STATA version 12.0 software were used. The correlation intensity was demonstrated with odds ratio （OR） and 95% confidence interval （CI）. Results A total of 6 publicationscontaining 9 studies （7 studies about primary biliary cirrhosis,2 studies about autoimmune hepatitis） published from January 2000 to February 2012 were identified and 844 cases and 1 522 controls were included. The combined results based on all studies showed that there was a statistlca^ly significant llnk between Apal and autoimmune liver diseases （OR = 0.85,95% CI 0.74 - 0.96, P=0.058, for a vs. A; OR = 0.75,95% CI 0.58 - 0.97,P = 0.212,for aa vs. AA;OR = 0.78,95% CI 0.63 - 0.98,P =0.235, for Aa vs. AA;OR = 0.77,95% CI 0.63 -0.94,P = 0.231,for Aa/aa vs. AA）,while the Bsml and Taql didn＇t show the association with autoimmunc liver diseases. Conclusion The current meta-analysis shows that Apal may be a low-penetrant risk factor for autoimmune liver diseases. Bsml and Taq 1 don＇t show the association with autoimmune liver diseases.

关 键 词：维生素D受体 基因多态性 自身免疫性肝病 Meta分析 

分 类 号：R575[医药卫生—消化系统]